BACKGROUND Living cells contain distinct subcompartments to facilitate spatiotemporal
regulation of biological reactions. In addition to canonical membrane-bound organelles such …

Eukaryotic cells compartmentalize their internal milieu in order to achieve specific reactions
in time and space. This organization in distinct compartments is essential to allow …

Tripartite motif (TRIM) proteins are a versatile family of ubiquitin E3 ligases involved in a
multitude of cellular processes. Studies in recent years have demonstrated that many TRIM …

Cells are organized on length scales ranging from ångström to micrometres. However, the
mechanisms by which ångström-scale molecular properties are translated to micrometre …

Stem-cell function is an exquisitely regulated process. Thus far, the contribution of metabolic
cues to stem-cell function has not been well understood. Here we identify a previously …

Proteins of the small ubiquitin-related modifier (SUMO) family are conjugated to proteins to
regulate such cellular processes as nuclear transport, transcription, chromosome …

Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

Polycomb proteins play essential roles in stem cell renewal and human disease. Recent
studies of HOX genes and X inactivation have provided evidence for RNA cofactors in …

Dynamic protein-rich intracellular structures that contain phase-separated intrinsically
disordered proteins (IDPs) composed of sequences of low complexity (SLC) have been …

Unlimited cellular proliferation depends on counteracting the telomere attrition that
accompanies DNA replication. In human cancers this usually occurs through upregulation of …