Mechanism of action of ribosomally synthesized and post-translationally modified peptides

C Ongpipattanakul, EK Desormeaux… - Chemical …, 2022 - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural
product class that has undergone significant expansion due to the rapid growth in genome …

Structural diversity, characterization and toxicology of microcystins

N Bouaïcha, CO Miles, DG Beach, Z Labidi, A Djabri… - Toxins, 2019 - mdpi.com
Hepatotoxic microcystins (MCs) are the most widespread class of cyanotoxins and the one
that has most often been implicated in cyanobacterial toxicosis. One of the main challenges …

Strategies to access biosynthetic novelty in bacterial genomes for drug discovery

F Hemmerling, J Piel - Nature Reviews Drug Discovery, 2022 - nature.com
Bacteria provide a rich source of natural products with potential therapeutic applications,
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …

[HTML][HTML] CyanoMetDB, a comprehensive public database of secondary metabolites from cyanobacteria

MR Jones, E Pinto, MA Torres, F Dörr, H Mazur-Marzec… - Water Research, 2021 - Elsevier
Harmful cyanobacterial blooms, which frequently contain toxic secondary metabolites, are
reported in aquatic environments around the world. More than two thousand cyanobacterial …

[HTML][HTML] Natural products from cyanobacteria: Focus on beneficial activities

J Demay, C Bernard, A Reinhardt, B Marie - Marine drugs, 2019 - mdpi.com
Cyanobacteria are photosynthetic microorganisms that colonize diverse environments
worldwide, ranging from ocean to freshwaters, soils, and extreme environments. Their …

Evolution and diversity of assembly-line polyketide synthases: focus review

A Nivina, KP Yuet, J Hsu, C Khosla - Chemical reviews, 2019 - ACS Publications
Assembly-line polyketide synthases (PKSs) are among the most complex protein
machineries known in nature, responsible for the biosynthesis of numerous compounds …

Deciphering the mechanism of fungal pathogen‐induced disease‐suppressive soil

T Wen, Z Ding, LS Thomashow, L Hale, S Yang… - New …, 2023 - Wiley Online Library
One model of a disease‐suppressive soil predicts that the confrontation of plant with a
phytopathogen can lead to the recruitment and accumulation of beneficial microorganisms …

The genetic and ecophysiological diversity of Microcystis

GJ Dick, MB Duhaime, JT Evans… - Environmental …, 2021 - Wiley Online Library
Microcystis is a cyanobacterium that forms toxic blooms in freshwater ecosystems around
the world. Biological variation among taxa within the genus is apparent through genetic and …

New applications of synthetic biology tools for cyanobacterial metabolic engineering

M Santos-Merino, AK Singh, DC Ducat - Frontiers in bioengineering …, 2019 - frontiersin.org
Cyanobacteria are promising microorganisms for sustainable biotechnologies, yet unlocking
their potential requires radical re-engineering and application of cutting-edge synthetic …

Secondary metabolism in the lichen symbiosis

MJ Calcott, DF Ackerley, A Knight… - Chemical Society …, 2018 - pubs.rsc.org
Lichens, which are defined by a core symbiosis between a mycobiont (fungal partner) and a
photobiont (photoautotrophic partner), are in fact complex assemblages of microorganisms …