Comprehensively charting the biologically causal circuits that govern the phenotypic space
of human cells has often been viewed as an insurmountable challenge. However, in the last …

High-throughput single-cell profiling provides an unprecedented ability to uncover the
molecular states of millions of cells. These technologies are, however, destructive to cells …

Even among genetically identical cancer cells, resistance to therapy frequently emerges
from a small subset of those cells,,,,,–. Molecular differences in rare individual cells in the …

Understanding and predicting molecular responses in single cells upon chemical, genetic or
mechanical perturbations is a core question in biology. Obtaining single-cell measurements …

Clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated
protein 9 (Cas9) is a powerful tool for introducing targeted mutations in DNA, but recent …

Latent variable models such as the Variational Auto-Encoder (VAE) have become a go-to
tool for analyzing biological data, especially in the field of single-cell genomics. One …

Across biological systems, cells undergo coordinated changes in gene expression, resulting
in transcriptome dynamics that unfold within a low-dimensional manifold. While low …

Recent advances in single-cell omics technology have transformed the landscape of cellular
and molecular research, enriching the scope and intricacy of cellular characterisation …

Assigning functions to genes and learning how to control their expression are part of the
foundation of cell biology and therapeutic development. An efficient and unbiased method to …

Over the last decade, biology has begun utilizing 'big data'approaches, resulting in large,
comprehensive atlases in modalities ranging from transcriptomics to neural connectomics …