Multimodal brain and retinal imaging of dopaminergic degeneration in Parkinson disease

JY Lee, A Martin-Bastida, A Murueta-Goyena… - Nature Reviews …, 2022 - nature.com
Parkinson disease (PD) is a progressive disorder characterized by dopaminergic
neurodegeneration in the brain. The development of parkinsonism is preceded by a long …

Retinal layers in Parkinson's disease: a meta-analysis of spectral-domain optical coherence tomography studies

A Chrysou, NM Jansonius, T van Laar - Parkinsonism & related disorders, 2019 - Elsevier
Abstract Background Patients with Parkinson's disease experience visual symptoms,
partially originating from retinal changes. Since 2011, multiple case-control studies using …

Retinal α-synuclein deposits in Parkinson's disease patients and animal models

L Veys, M Vandenabeele, I Ortuno-Lizaran… - Acta …, 2019 - Springer
Despite decades of research, accurate diagnosis of Parkinson's disease remains a
challenge, and disease-modifying treatments are still lacking. Research into the early …

Optic nerve and macular optical coherence tomography in recovered COVID-19 patients

B Burgos-Blasco, N Güemes-Villahoz… - European Journal …, 2022 - journals.sagepub.com
Purpose: To investigate the peripapillary retinal nerve fiber layer thickness (RNFLT),
macular RNFLT, ganglion cell layer (GCL), and inner plexiform layer (IPL) thickness in …

Retinal correlates of neurological disorders

TE Yap, SI Balendra, MT Almonte… - … advances in chronic …, 2019 - journals.sagepub.com
Considering the retina as an extension of the brain provides a platform from which to study
diseases of the nervous system. Taking advantage of the clear optical media of the eye and …

Dopamine, alpha-synuclein, and mitochondrial dysfunctions in parkinsonian eyes

A Indrieri, R Pizzarelli, B Franco… - Frontiers in …, 2020 - frontiersin.org
Parkinson's disease (PD) is characterized by motor dysfunctions including bradykinesia,
tremor at rest and motor instability. These symptoms are associated with the progressive …

Optical coherence tomography measurements as potential imaging biomarkers for Parkinson's disease: a systematic review and meta‐analysis

WC Zhou, JX Tao, J Li - European Journal of Neurology, 2021 - Wiley Online Library
Background and purpose Retinal pathological changes may precede or accompany the
deterioration of brain tissue in Parkinson's disease (PD). The purpose of this meta‐analysis …

Does retina play a role in Parkinson's Disease?

S Mohana Devi, I Mahalaxmi, NP Aswathy… - Acta Neurologica …, 2020 - Springer
Visual disorder is one of the non-motor symptoms found in Parkinson's disease (PD). It can
be easily identified in the early stages even before the spread of pathological conditions to …

The specific pattern of retinal nerve fiber layer thinning in Parkinson's disease: a systematic review and meta-analysis

L Huang, C Wang, W Wang, Y Wang, R Zhang - Journal of Neurology, 2021 - Springer
Background and purpose The peripapillar nerve fiber layer (pRNFL) thinning in different
retinal quadrants or sectors remains controversy. We conducted a systematic review and …

The role of alpha-synuclein deposits in Parkinson's disease: a focus on the human retina

M Di Pippo, S Fragiotta, F Di Staso, L Scuderi… - International Journal of …, 2023 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative condition characterized by the progressive
deterioration of dopaminergic neurons in the central and peripheral autonomous system and …