Cardiac myosin-binding protein C (MYBPC3) in cardiac pathophysiology
More than 350 individual MYPBC3 mutations have been identified in patients with inherited
hypertrophic cardiomyopathy (HCM), thus representing 40–50% of all HCM mutations …
hypertrophic cardiomyopathy (HCM), thus representing 40–50% of all HCM mutations …
Small angle X-ray diffraction as a tool for structural characterization of muscle disease
Small angle X-ray fiber diffraction is the method of choice for obtaining molecular level
structural information from striated muscle fibers under hydrated physiological conditions …
structural information from striated muscle fibers under hydrated physiological conditions …
Under construction: The dynamic assembly, maintenance, and degradation of the cardiac sarcomere
The sarcomere is the basic contractile unit of striated muscle and is a highly ordered protein
complex with the actin and myosin filaments at its core. Assembling the sarcomere …
complex with the actin and myosin filaments at its core. Assembling the sarcomere …
Regulation of contraction by the thick filaments in skeletal muscle
M Irving - Biophysical journal, 2017 - cell.com
Contraction of skeletal muscle cells is initiated by a well-known signaling pathway. An action
potential in a motor nerve triggers an action potential in a muscle cell membrane, a transient …
potential in a motor nerve triggers an action potential in a muscle cell membrane, a transient …
An update on MYBPC3 gene mutation in hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is the most prevalent genetically inherited
cardiomyopathy that follows an autosomal dominant inheritance pattern. The majority of …
cardiomyopathy that follows an autosomal dominant inheritance pattern. The majority of …
Myosin binding protein-C activates thin filaments and inhibits thick filaments in heart muscle cells
T Kampourakis, Z Yan, M Gautel… - Proceedings of the …, 2014 - National Acad Sciences
Myosin binding protein-C (MyBP-C) is a key regulatory protein in heart muscle, and
mutations in the MYBPC3 gene are frequently associated with cardiomyopathy. However …
mutations in the MYBPC3 gene are frequently associated with cardiomyopathy. However …
Slower Calcium Handling Balances Faster Cross-Bridge Cycling in Human MYBPC3 HCM
Background: The pathogenesis of MYBPC3-associated hypertrophic cardiomyopathy (HCM)
is still unresolved. In our HCM patient cohort, a large and well-characterized population …
is still unresolved. In our HCM patient cohort, a large and well-characterized population …
[HTML][HTML] Thick filament protein network, functions, and disease association
L Wang, J Geist, A Grogan, LYR Hu… - Comprehensive …, 2018 - ncbi.nlm.nih.gov
Sarcomeres consist of highly ordered arrays of thick myosin and thin actin filaments along
with accessory proteins. Thick filaments occupy the center of sarcomeres where they …
with accessory proteins. Thick filaments occupy the center of sarcomeres where they …
The genetic basis of hypertrophic cardiomyopathy in cats and humans
Mutations in genes that encode for muscle sarcomeric proteins have been identified in
humans and two breeds of domestic cats with hypertrophic cardiomyopathy (HCM). This …
humans and two breeds of domestic cats with hypertrophic cardiomyopathy (HCM). This …
RBPMS2 is a myocardial-enriched splicing regulator required for cardiac function
Background: RBPs (RNA-binding proteins) perform indispensable functions in the post-
transcriptional regulation of gene expression. Numerous RBPs have been implicated in …
transcriptional regulation of gene expression. Numerous RBPs have been implicated in …