Protein tyrosine kinases (PTKs) are a class of proteins with tyrosine kinase activity that
phosphorylate tyrosine residues of critical molecules in signaling pathways. Their basal …

Simple Summary The genomics-based concept of precision medicine began to emerge
following the completion of the Human Genome Project. In contrast to evidence-based …

Immune checkpoint blockade (ICB) therapy has achieved breakthroughs in the treatment of
advanced non–small cell lung cancer (NSCLC). Nevertheless, the low response due to …

One of the leading causes of death worldwide, in both men and women, is cancer. Despite
the significant development in therapeutic strategies, the inevitable emergence of drug …

Non‐small‐cell lung cancer (NSCLC), which has a high rate of metastatic spread and drug
resistance, is the most common subtype of lung cancer. Therefore, NSCLC patients have a …

Significance: Cholesterol is a type of lipid that plays a crucial role in building and
maintaining cell membranes, producing certain hormones, and aiding in digestion. The two …

Hyperuricemic nephropathy (HN) is a global metabolic disorder characterized by uric acid
(UA) metabolism dysfunction, resulting in hyperuricemia (HUA) and tubulointerstitial fibrosis …

Dysregulation of cholesterol homeostasis occurs in multiple types of tumors and promotes
cancer progression. Investigating the specific processes that induce abnormal cholesterol …

Epidermal growth factor receptor (EGFR) mutation is the most common driver mutation in
non-small cell lung cancer (NSCLC). The first-line therapy for advanced NSCLC patients …

Background Lipid metabolism has been implicated in a variety of normal cellular processes
and strongly related to the development of multiple diseases, including tumor. Tumor …