Immunomodulatory roles of PARPs: Sha** the tumor microenvironment, one ADP-ribose at a time
PARPs encompass a small yet pervasive group of 17 enzymes that catalyze a post-
translational modification known as ADP-ribosylation. PARP1, the founding member, has …
translational modification known as ADP-ribosylation. PARP1, the founding member, has …
Improving PARP inhibitor efficacy in high-grade serous ovarian carcinoma: A focus on the immune system
High-grade serous ovarian carcinoma (HGSOC) is a genomically unstable malignancy
responsible for over 70% of all deaths due to ovarian cancer. With roughly 50% of all …
responsible for over 70% of all deaths due to ovarian cancer. With roughly 50% of all …
NLR and BRCA mutational status in patients with high grade serous advanced ovarian cancer
C Marchetti, M D'Indinosante, C Bottoni, C Di Ilio… - Scientific Reports, 2021 - nature.com
Laboratory-markers of the systemic inflammatory-response, such as neutrophil/lymphocyte-
ratio (NLR) have been studied as prognostic factors in several tumors but in OC-patients …
ratio (NLR) have been studied as prognostic factors in several tumors but in OC-patients …
Mechanism research and treatment progress of NAD pathway related molecules in tumor immune microenvironment
QC Xu, X Liu, G Mohseni, X Hao, Y Ren, Y Xu… - Cancer Cell …, 2022 - Springer
Nicotinamide adenine dinucleotide (NAD) is the core of cellular energy metabolism. NAMPT,
Sirtuins, PARP, CD38, and other molecules in this classic metabolic pathway affect many …
Sirtuins, PARP, CD38, and other molecules in this classic metabolic pathway affect many …
Cytotoxic and targeted therapy for BRCA1/2-driven cancers
EN Imyanitov - Hereditary Cancer in Clinical Practice, 2021 - Springer
Tumors arising in BRCA1/2 germline mutation carriers usually demonstrate somatic loss of
the remaining BRCA1/2 allele and increased sensitivity to platinum compounds …
the remaining BRCA1/2 allele and increased sensitivity to platinum compounds …
Combining PARP Inhibition and Immunotherapy in BRCA-Associated Cancers
GI Shapiro, SM Barry - Targeting the DNA Damage Response for Cancer …, 2023 - Springer
Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors have significantly improved
treatment outcomes of homologous recombination (HR) repair-deficient cancers. While the …
treatment outcomes of homologous recombination (HR) repair-deficient cancers. While the …
Innate immunity mediator STING modulates nascent DNA metabolism at stalled forks in human cells
P Lazarchuk, VN Nguyen, S Brunon… - Frontiers in Molecular …, 2023 - frontiersin.org
Background: The cGAS/STING pathway, part of the innate immune response to foreign DNA,
can be activated by cell's own DNA arising from the processing of the genome, including the …
can be activated by cell's own DNA arising from the processing of the genome, including the …
Preclinical evaluation of a novel pet tracer for imaging PARP1 in glioblastoma
D Ojha, B Chen, T Toyonaga, R Pracitto, M Liu… - 2021 - Soc Nuclear Med
152 Introduction: Glioblastoma tumor cells can utilize DNA repairing process mediated by
poly (ADP-ribose) polymerase-1/2 (PARP-1/2). Thus, partly due to the increased activity of …
poly (ADP-ribose) polymerase-1/2 (PARP-1/2). Thus, partly due to the increased activity of …
Innate immunity mediator STING modulates nascent DNA metabolism at stalled forks in human cells
VN Nguyen, S Brunon, MN Pavlova, P Lazarchuk… - bioRxiv, 2021 - biorxiv.org
The cGAS/STING pathway, part of the innate immune response to foreign DNA, is known to
be activated by cell's own DNA arising from the processing of the genome, including the …
be activated by cell's own DNA arising from the processing of the genome, including the …
Nlr & Brca Mutational Status In Patients With High Grade Serous Advanced Ovarian Cancer: A Large Population Study
C Marchetti, M D'Indinosante, C Bottoni, C Di Ilio… - 2021 - researchsquare.com
Laboratory-markers of the systemic inflammatory-response, such as neutrophil/lymphocyte-
ratio (NLR) have been studied as prognostic factors in several tumors but in OC-patients …
ratio (NLR) have been studied as prognostic factors in several tumors but in OC-patients …