Piper species are aromatic plants used as spices in the kitchen, but their secondary
metabolites have also shown biological effects on human health. These plants are rich in …

The need for innovative anticancer treatments with high effectiveness and low toxicity is
urgent due to the development of malignancies that are resistant to chemotherapeutic …

Background Cancer management faces multiple obstacles, including resistance to current
therapeutic approaches. In the face of challenging microenvironments, cancer cells adapt …

Chalcones are precursors of flavonoid biosynthesis in plants. Both flavonoids and chalcones
are intensively investigated because of a large spectrum of their biological activities. Among …

Simple Summary Despite the important progress in cancer treatment in the past decades,
the mortality rates in some types of cancer have not significantly decreased. Therefore, the …

Kava beverages are typically prepared from the root of Piper methysticum. They have been
consumed among Pacific Islanders for centuries. Kava extract preparations were once used …

The zebrafish (Danio rerio) is an emerging model system in several research areas
worldwide, especially in the Global South. In this context, the present study revised the …

Inflammatory bowel disease (IBD) is characterized by recurrent inflammatory reactions in the
intestinal mucosa, including ulcerative colitis (UC) and Crohn's disease (CD). The …

Chalcones, a class of secondary metabolites within the flavonoid family, are characterized
by a distinct C6-C3-C6 structure. They are prevalent in both edible and medicinal plants and …

Chalcones containing amino or acetamide groups on ring A and electron
donating/withdrawing groups on ring B have been shown to have great cytotoxic potential …