Targeting integrins for cancer therapy-disappointments and opportunities
C Bergonzini, K Kroese, AJM Zweemer… - Frontiers in Cell and …, 2022 - frontiersin.org
Integrins mediate adhesive interactions between cells and their environment, including
neighboring cells and extracellular matrix (ECM). These heterodimeric transmembrane …
neighboring cells and extracellular matrix (ECM). These heterodimeric transmembrane …
The lipid rafts in cancer stem cell: a target to eradicate cancer
S Zhang, N Zhu, HF Li, J Gu, CJ Zhang, DF Liao… - Stem Cell Research & …, 2022 - Springer
Cancer stem cells (CSCs) are a subpopulation of cancer cells with stem cell properties that
sustain cancers, which may be responsible for cancer metastasis or recurrence. Lipid rafts …
sustain cancers, which may be responsible for cancer metastasis or recurrence. Lipid rafts …
The desmoplastic stroma of pancreatic cancer: multilayered levels of heterogeneity, clinical significance, and therapeutic opportunities
Y Masugi - Cancers, 2022 - mdpi.com
Simple Summary Pancreatic cancer is a highly malignant disease with treatment resistance
to standardized chemotherapies. In addition, only a small fraction of patients with pancreatic …
to standardized chemotherapies. In addition, only a small fraction of patients with pancreatic …
Mebendazole prevents distant organ metastases in part by decreasing ITGβ4 expression and cancer stemness
Breast cancer is the most diagnosed cancer among women. Approximately 15–20% of all
breast cancers are highly invasive triple-negative breast cancer (TNBC) and lack estrogen …
breast cancers are highly invasive triple-negative breast cancer (TNBC) and lack estrogen …
Rough neighborhood: Intricacies of cancer stem cells and infiltrating immune cell interaction in tumor microenvironment and potential in therapeutic targeting.
K Mahanti, S Bhattacharyya - Translational Research, 2024 - Elsevier
Ongoing research on cellular heterogeneity of Cancer stem cells (CSCs) and its synergistic
involvement with tumor milieu reveals enormous complexity, resulting in diverse hindrance …
involvement with tumor milieu reveals enormous complexity, resulting in diverse hindrance …
[HTML][HTML] Meta-analysis of expression and the targeting of cell adhesion associated genes in nine cancer types–A one research lab re-evaluation
O Borodins, F Broghammer, M Seifert… - Computational and …, 2023 - Elsevier
Cancer presents as a highly heterogeneous disease with partly overlap** and partly
distinct (epi) genetic characteristics. These characteristics determine inherent and acquired …
distinct (epi) genetic characteristics. These characteristics determine inherent and acquired …
ITGB4 is a prognostic biomarker and correlated with lung adenocarcinoma brain metastasis
J Zhang, L Li, W Luo, S Ma, Y Zhao - Clinical and Translational Oncology, 2024 - Springer
Background The aim of this study is to explore the prognostic value and immune signature of
ITGB4 expression in lung adenocarcinoma (LUAD) brain metastasis. Methods We …
ITGB4 expression in lung adenocarcinoma (LUAD) brain metastasis. Methods We …
[PDF][PDF] Zweemer
C Bergonzini, K Kroese - M., & Danen, EH, 2022 - scholarlypublications …
Integrins mediate adhesive interactions between cells and their environment, including
neighboring cells and extracellular matrix (ECM). These heterodimeric transmembrane …
neighboring cells and extracellular matrix (ECM). These heterodimeric transmembrane …