Context.—Controversies and uncertainty persist in prostate cancer grading. Objective.—To
update grading recommendations. Data Sources.—Critical review of the literature along with …

Gleason grade of adenocarcinoma of the prostate is an established prognostic indicator that
has stood the test of time. The Gleason grading method was devised in the 1960s and …

Prostate cancer has the highest prevalence of any nonskin cancer in the human body, with
similar likelihood of neoplastic foci found within the prostates of men around the world …

Prostate and breast cancer are the two cancers with the highest incidence in men and
women, respectively. Here, we focus on the known biology of acquired resistance to …

Purpose: The restricted expression of the surface glycoprotein prostrate-specific membrane
antigen (PSMA) to normal prostate tissue, primary and metastatic prostate cancer (PCa), and …

It is now accepted that the growth of solid tumours is dependent on their capacity to acquire
a blood supply, and much effort has been directed towards the development of agents …

High-density tissue microarrays (TMA) are useful for profiling protein expression in a large
number of samples but their use for clinical biomarker studies may be limited in …

BACKGROUND Wnt‐1 and β‐catenin expression levels play an important role in several
malignancies. The authors determined the level of production of Wnt‐1 and β‐catenin in …

This paper, based on the activity of the Morphology-Based Prognostic Factors Committee of
the 2004 World Health Organization-sponsored International Consultation, describes …

Molecular markers have the potential to serve not only as prognostic factors but may be
targets for new therapeutic strategies and predictors of response in a range of cancers …