The Known, the Unknown and the Future of the Pathophysiology of Endometriosis

MA Ochoa Bernal, AT Fazleabas - International Journal of Molecular …, 2024 - mdpi.com
Endometriosis is one of the most common causes of chronic pelvic pain and infertility,
affecting 10% of women of reproductive age. A delay of up to 9 years is estimated between …

Epigenetic regulation and T-cell responses in endometriosis–something other than autoimmunity

D Szukiewicz - Frontiers in immunology, 2022 - frontiersin.org
Endometriosis is defined as the presence of endometrial-like glands and stroma located
outside the uterine cavity. This common, estrogen dependent, inflammatory condition affects …

Clinical consequences of defective decidualization

C Ticconi, N Di Simone, L Campagnolo, A Fazleabas - Tissue and Cell, 2021 - Elsevier
Decidualization is characterized by a series of genetic, metabolic, morphological,
biochemical, vascular and immune changes occurring in the endometrial stroma in …

What do we know about regulatory T cells and endometriosis? A systematic review

IBL de Barros, H Malvezzi… - Journal of reproductive …, 2017 - Elsevier
Endometriosis is a benign, chronic inflammatory disease that presents alterations in immune
response that can be detected in eutopic endometrium, peritoneal fluid and peripheral blood …

Effects of endometriosis on immunity and mucosal microbial community dynamics in female olive baboons

N Le, M Cregger, A Fazleabas… - Scientific Reports, 2022 - nature.com
Endometriosis is defined as the growth of endometrial tissue in ectopic locations, and is
associated with altered immune and microbial phenotypes. It is unclear if these changes are …

1-Methyl-tryptophan attenuates regulatory T cells differentiation due to the inhibition of estrogen-IDO1-MRC2 axis in endometriosis

C Wei, J Mei, L Tang, Y Liu, D Li, M Li, X Zhu - Cell death & disease, 2016 - nature.com
Foxp3+ regulatory T (T reg) cells contribute to the local dysfunctional immune environment
in endometriosis, an estrogen-dependent gynecological disease, which affects the function …

MCP-1 exerts the inflammatory response via ILK activation during endometriosis pathogenesis

UK Soni, R Tripathi, RK Jha - Life Sciences, 2024 - Elsevier
Aims MCP-1 has been shown to be elevated in endometriosis. ILK functions in several
cellular events and interacts with MCP-1-signaling. In the current study, we evaluated the …

Alteration of systemic and uterine endometrial immune populations in patients with endometriosis

NXH Le, JR Loret de Mola, P Bremer… - American Journal of …, 2021 - Wiley Online Library
Problem Endometriosis is defined as growth of endometrial tissue in ectopic locations; it is
associated with infertility and chronic pain and affects~ 12% of reproductive‐aged women …

[HTML][HTML] Interleukin-33 derived from endometriotic lesions promotes fibrogenesis through inducing the production of profibrotic cytokines by regulatory T cells

F **ao, X Liu, SW Guo - Biomedicines, 2022 - mdpi.com
In endometriosis, it has been widely believed that the local immunological milieu is Th2-
skewed. Regulatory T cells (Tregs) promote fibrogenesis of endometriosis through the …

Higher frequency of circulating, but not tissue regulatory T cells in patients with endometriosis

AA Delbandi, M Mahmoudi, A Shervin, Z Moradi… - Journal of reproductive …, 2020 - Elsevier
Background Endometriosis is one of the most common chronic gynecological disorders
affecting women at reproductive age. Dysregulation of immune cells, including regulatory T …