Recent advances in mitochondrial aminoacyl-tRNA synthetases and disease
M Sissler, LE González-Serrano, E Westhof - Trends in molecular medicine, 2017 - cell.com
Dysfunctions in mitochondria–the powerhouses of the cell–lead to several human
pathologies. Because mitochondria integrate nuclear and mitochondrial genetic systems …
pathologies. Because mitochondria integrate nuclear and mitochondrial genetic systems …
Fracture toughness of thermoelectric materials
The engineering applications of thermoelectric (TE) devices require TE materials
possessing high TE performance and robust mechanical properties. Research on thermal …
possessing high TE performance and robust mechanical properties. Research on thermal …
Widespread translational control of fibrosis in the human heart by RNA-binding proteins
Background: Fibrosis is a common pathology in many cardiac disorders and is driven by the
activation of resident fibroblasts. The global posttranscriptional mechanisms underlying …
activation of resident fibroblasts. The global posttranscriptional mechanisms underlying …
Roles of aminoacyl-tRNA synthetases in immune regulation and immune diseases
A Nie, B Sun, Z Fu, D Yu - Cell death & disease, 2019 - nature.com
Aminoacyl-tRNA synthetases (ARSs) play a vital role in protein synthesis by linking amino
acids to their cognate transfer RNAs (tRNAs). This typical function has been well recognized …
acids to their cognate transfer RNAs (tRNAs). This typical function has been well recognized …
RNA granule-clustered mitochondrial aminoacyl-tRNA synthetases form multiple complexes with the potential to fine-tune tRNA aminoacylation
GX Peng, XL Mao, Y Cao, SY Yao, QR Li… - Nucleic Acids …, 2022 - academic.oup.com
Mitochondrial RNA metabolism is suggested to occur in identified compartmentalized foci, ie
mitochondrial RNA granules (MRGs). Mitochondrial aminoacyl-tRNA synthetases (mito …
mitochondrial RNA granules (MRGs). Mitochondrial aminoacyl-tRNA synthetases (mito …
Rat models of human diseases and related phenotypes: a systematic inventory of the causative genes
C Szpirer - Journal of biomedical science, 2020 - Springer
The laboratory rat has been used for a long time as the model of choice in several
biomedical disciplines. Numerous inbred strains have been isolated, displaying a wide …
biomedical disciplines. Numerous inbred strains have been isolated, displaying a wide …
Mitochondrial aminoacyl-tRNA synthetase disorders: an emerging group of developmental disorders of myelination
Background The mitochondrial aminoacyl-tRNA synthetase proteins (mt-aaRSs) are a group
of nuclear-encoded enzymes that facilitate conjugation of each of the 20 amino acids to its …
of nuclear-encoded enzymes that facilitate conjugation of each of the 20 amino acids to its …
The regulatory roles of aminoacyl-tRNA synthetase in cardiovascular disease
Y Zou, Y Yang, X Fu, X He, M Liu, T Zong, X Li… - … Therapy-Nucleic Acids, 2021 - cell.com
Aminoacyl-tRNA synthetases (ARSs) are widely found in organisms, which can activate
amino acids and make them bind to tRNA through ester bond to form the corresponding …
amino acids and make them bind to tRNA through ester bond to form the corresponding …
Mutations of the aminoacyl‐tRNA‐synthetases SARS and WARS2 are implicated in the etiology of autosomal recessive intellectual disability
Intellectual disability (ID) is the hallmark of an extremely heterogeneous group of disorders
that comprises a wide variety of syndromic and non‐syndromic phenotypes. Here, we report …
that comprises a wide variety of syndromic and non‐syndromic phenotypes. Here, we report …
The role of nuclear-encoded mitochondrial tRNA charging enzymes in human inherited disease
C Del Greco, A Antonellis - Genes, 2022 - mdpi.com
Aminoacyl-tRNA synthetases (ARSs) are highly conserved essential enzymes that charge
tRNA with cognate amino acids—the first step of protein synthesis. Of the 37 nuclear …
tRNA with cognate amino acids—the first step of protein synthesis. Of the 37 nuclear …