Tumor microenvironment and epithelial mesenchymal transition as targets to overcome tumor multidrug resistance
It is well established that multifactorial drug resistance hinders successful cancer treatment.
Tumor cell interactions with the tumor microenvironment (TME) are crucial in epithelial …
Tumor cell interactions with the tumor microenvironment (TME) are crucial in epithelial …
Stimuli-responsive nano-architecture drug-delivery systems to solid tumor micromilieu: past, present, and future perspectives
The microenvironment characteristics of solid tumors, renowned as barriers that harshly
impeded many drug-delivery approaches, were precisely studied, investigated, categorized …
impeded many drug-delivery approaches, were precisely studied, investigated, categorized …
Targeting EGFR exon 20 insertion mutations in non-small cell lung cancer
Inframe insertions of three or more base pairs in exon 20 of the epidermal growth factor
receptor (EGFR) gene were among the first EGFR mutations to be identified as oncogenic …
receptor (EGFR) gene were among the first EGFR mutations to be identified as oncogenic …
[HTML][HTML] Cisplatin-resistant NSCLC cells induced by hypoxia transmit resistance to sensitive cells through exosomal PKM2
D Wang, C Zhao, F Xu, A Zhang, M **, K Zhang… - Theranostics, 2021 - ncbi.nlm.nih.gov
Hypoxia is commonly observed in solid tumors and contributes to the resistance of DNA
damage drugs. However, the mechanisms behind this resistance are still unclear. In this …
damage drugs. However, the mechanisms behind this resistance are still unclear. In this …
Lactate modulates cellular metabolism through histone lactylation-mediated gene expression in non-small cell lung cancer
J Jiang, DL Huang, Y Jiang, J Hou, MY Tian… - Frontiers in …, 2021 - frontiersin.org
Lactate has been observed to fuel TCA cycle and is associated with cancer progression in
human lung cancer, the leading cause of cancer deaths worldwide, but the effect of lactate …
human lung cancer, the leading cause of cancer deaths worldwide, but the effect of lactate …
Changes in CT radiomic features associated with lymphocyte distribution predict overall survival and response to immunotherapy in non–small cell lung cancer
No predictive biomarkers can robustly identify patients with non–small cell lung cancer
(NSCLC) who will benefit from immune checkpoint inhibitor (ICI) therapies. Here, in a …
(NSCLC) who will benefit from immune checkpoint inhibitor (ICI) therapies. Here, in a …
Hypoxia as a barrier to immunotherapy in pancreatic adenocarcinoma
SK Daniel, KM Sullivan, KP Labadie… - Clinical and translational …, 2019 - Springer
Pancreatic ductal adenocarcinoma (PDA) is a lethal disease with limited response to
cytotoxic chemoradiotherapy, as well as newer immunotherapies. The PDA tumor …
cytotoxic chemoradiotherapy, as well as newer immunotherapies. The PDA tumor …
Intrinsic Resistance to EGFR-Tyrosine Kinase Inhibitors in EGFR-Mutant Non-Small Cell Lung Cancer: Differences and Similarities with Acquired Resistance
Activating mutations in the epidermal growth factor receptor gene occur as early cancer-
driving clonal events in a subset of patients with non-small cell lung cancer (NSCLC) and …
driving clonal events in a subset of patients with non-small cell lung cancer (NSCLC) and …
Defeating relapsed and refractory malignancies through a nano-enabled mitochondria-mediated respiratory inhibition and damage pathway
Hypoxia, which frequently reduces the sensitivity to many therapeutic interventions,
including chemotherapy, radiotherapy and phototherapy, has been acknowledged as an …
including chemotherapy, radiotherapy and phototherapy, has been acknowledged as an …
Imaging tumour hypoxia with oxygen-enhanced MRI and BOLD MRI
JPB O'Connor, SP Robinson… - The British journal of …, 2019 - academic.oup.com
Hypoxia is known to be a poor prognostic indicator for nearly all solid tumours and also is
predictive of treatment failure for radiotherapy, chemotherapy, surgery and targeted …
predictive of treatment failure for radiotherapy, chemotherapy, surgery and targeted …