Training-induced changes in mitochondrial content and respiratory function in human skeletal muscle

C Granata, NA Jamnick, DJ Bishop - Sports Medicine, 2018 - Springer
A sedentary lifestyle has been linked to a number of metabolic disorders that have been
associated with sub-optimal mitochondrial characteristics and an increased risk of …

The regulation of fat metabolism during aerobic exercise

A Muscella, E Stefàno, P Lunetti, L Capobianco… - Biomolecules, 2020 - mdpi.com
Since the lipid profile is altered by physical activity, the study of lipid metabolism is a
remarkable element in understanding if and how physical activity affects the health of both …

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans

PA Andreux, W Blanco-Bose, D Ryu, F Burdet… - Nature …, 2019 - nature.com
Urolithin A (UA) is a natural dietary, microflora-derived metabolite shown to stimulate
mitophagy and improve muscle health in old animals and in preclinical models of aging …

Tuning fatty acid oxidation in skeletal muscle with dietary fat and exercise

AM Fritzen, AM Lundsgaard, B Kiens - Nature Reviews Endocrinology, 2020 - nature.com
Both the consumption of a diet rich in fatty acids and exercise training result in similar
adaptations in several skeletal muscle proteins. These adaptations are involved in fatty acid …

Acyl-CoA metabolism and partitioning

TJ Grevengoed, EL Klett… - Annual review of …, 2014 - annualreviews.org
Long-chain fatty acyl-coenzyme As (CoAs) are critical regulatory molecules and metabolic
intermediates. The initial step in their synthesis is the activation of fatty acids by one of 13 …

Mitochondrial adaptations to high‐volume exercise training are rapidly reversed after a reduction in training volume in human skeletal muscle

C Granata, RSF Oliveira, JP Little, K Renner… - The FASEB …, 2016 - Wiley Online Library
Increased mitochondrial content and respiration have both been reported after exercise
training. However, no study has directly compared how different training volumes influence …

[HTML][HTML] The relationship between skeletal muscle mitochondrial citrate synthase activity and whole body oxygen uptake adaptations in response to exercise training

A Vigelsø, NB Andersen, F Dela - International journal of …, 2014 - ncbi.nlm.nih.gov
Citrate synthase (CS) activity is a validated biomarker for mitochondrial density in skeletal
muscle. CS activity is also used as a biochemical marker of the skeletal muscle oxidative …

Clinical trials targeting aging

JL Nielsen, D Bakula, M Scheibye-Knudsen - Frontiers in aging, 2022 - frontiersin.org
The risk of morbidity and mortality increases exponentially with age. Chronic inflammation,
accumulation of DNA damage, dysfunctional mitochondria, and increased senescent cell …

Effects of dietary n-6: n-3 PUFA ratio on fatty acid composition, free amino acid profile and gene expression of transporters in finishing pigs

F Li, Y Duan, Y Li, Y Tang, M Geng… - British Journal of …, 2015 - cambridge.org
Revealing the expression patterns of fatty acid and amino acid transporters as affected by
dietary n-6: n-3 PUFA ratio would be useful for further clarifying the importance of the …

Dietary DHA/EPA ratio affects growth, tissue fatty acid profiles and expression of genes involved in lipid metabolism in mud crab Scylla paramamosain supplied with …

X Wang, M **, X Cheng, X Hu, M Zhao, Y Yuan, P Sun… - Aquaculture, 2021 - Elsevier
An 8-week feeding trial was conducted to determine the optimal dietary docosahexaenoic
acid/eisosapentaenoic acid (DHA/EPA) ratio of mud crab (Scylla paramamosain) supplied …