Same species, different diseases: how and why typhoidal and non-typhoidal Salmonella enterica serovars differ

O Gal-Mor, EC Boyle, GA Grassl - Frontiers in microbiology, 2014 - frontiersin.org
Human infections by the bacterial pathogen Salmonella enterica represent major disease
burdens worldwide. This highly ubiquitous species consists of more than 2600 different …

Salmonella enterica Serovar Typhi and the Pathogenesis of Typhoid Fever

G Dougan, S Baker - Annual review of microbiology, 2014 - annualreviews.org
Salmonella enterica serovar Typhi, the cause of typhoid, is host restricted to humans. S.
Typhi has a monophyletic population structure, indicating that typhoid in humans is a …

One species, different diseases: the unique molecular mechanisms that underlie the pathogenesis of typhoidal Salmonella infections

BX Wang, DSC Butler, M Hamblin… - Current opinion in …, 2023 - Elsevier
Highlights•Salmonella enterica is comprised of non-typhoidal and typhoidal
serovars.•Typhoidal Salmonella causes enteric fever instead of self-limiting …

Immunity to Intracellular Salmonella Depends on Surface-associated Antigens

S Barat, Y Willer, K Rizos, B Claudi, A Mazé… - 2012 - journals.plos.org
Invasive Salmonella infection is an important health problem that is worsening because of
rising antimicrobial resistance and changing Salmonella serovar spectrum. Novel vaccines …

Complex adaptive immunity to enteric fevers in humans: lessons learned and the path forward

MB Sztein, R Salerno-Goncalves… - Frontiers in …, 2014 - frontiersin.org
Salmonella enterica serovar Typhi (S. Typhi), the causative agent of typhoid fever, and S.
Paratyphi A and B, causative agents of paratyphoid fever, are major public health threats …

Evaluation of a Typhoid/Paratyphoid Diagnostic Assay (TPTest) Detecting Anti-Salmonella IgA in Secretions of Peripheral Blood Lymphocytes in Patients in Dhaka …

F Khanam, A Sheikh, MA Sayeed… - PLoS neglected …, 2013 - journals.plos.org
Background Rapid and reliable diagnostic assays for enteric (typhoid and paratyphoid) fever
are urgently needed. We report the characterization of novel approach utilizing lymphocyte …

Live Attenuated Human Salmonella Vaccine Candidates: Tracking the Pathogen in Natural Infection and Stimulation of Host Immunity

JE Galen, AD Buskirk, SM Tennant, MF Pasetti - EcoSal Plus, 2016 - Am Soc Microbiol
Salmonellosis, caused by members of the genus Salmonella, is responsible for
considerable global morbidity and mortality in both animals and humans. In this review, we …

Evasion of MAIT cell recognition by the African Salmonella Typhimurium ST313 pathovar that causes invasive disease

L Preciado-Llanes, A Aulicino… - Proceedings of the …, 2020 - National Acad Sciences
Mucosal-associated invariant T (MAIT) cells are innate T lymphocytes activated by bacteria
that produce vitamin B2 metabolites. Mouse models of infection have demonstrated a role …

Plasma Immunoglobulin A Responses Against 2 Salmonella Typhi Antigens Identify Patients With Typhoid Fever

JR Andrews, F Khanam, N Rahman… - Clinical Infectious …, 2019 - academic.oup.com
Background There is a need for a reliable, simple diagnostic assay for typhoid fever.
Available commercial serologic assays for typhoid fever have limited sensitivity and …

Clonal analysis of Salmonella-specific effector T cells reveals serovar-specific and cross-reactive T cell responses

G Napolitani, P Kurupati, KWW Teng, MM Gibani… - Nature …, 2018 - nature.com
To tackle the complexity of cross-reactive and pathogen-specific T cell responses against
related Salmonella serovars, we used mass cytometry, unbiased single-cell cloning, live …