Glycans on proteins and lipids are known to alter with malignant transformation. The study of
these may contribute to the discovery of biomarkers and treatment targets as well as …

Fucosylation is the process of transferring fucose from GDP-fucose to their substrates, which
includes certain proteins, N-and O-linked glycans in glycoprotein or glycolipids, by …

Glycans are one of the fundamental classes of macromolecules and are involved in a broad
range of biological phenomena. A large variety of glycan structures can be synthesized …

Protein glycosylation represents a nearly ubiquitous post-translational modification, and
altered glycosylation can result in clinically significant pathological consequences. Here we …

Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths in the world.
Drug resistance of tumour cells remains the main challenge toward curative treatments …

Highlights•Aberrant fucosylation is a signature of malignant cell transformation and
modulates the occurrence and development of cancer.•Targeting fucosyltransferases (FUTs) …

Advances in colorectal cancer (CRC) diagnosis will be enhanced by development of more
sensitive and reliable methods for early detection of the disease when treatment is more …

Colorectal cancer (CRC)–associated changes of protein glycosylation have been widely
studied. In contrast, the expression of glycosphingolipid (GSL) patterns in CRC has, hitherto …

Gastrointestinal (GI) cancer is the most common group of malignancies and many of its types
are among the most deadly. Various glycoconjugates have been used in clinical practice as …

The epithelial-mesenchymal transition (EMT) is an essential step in the proliferation and
metastasis of solid tumor cells, and glycosylation plays a crucial role in the EMT process …