Macrophage: a cell with many faces and functions in tuberculosis
Mycobacterium tuberculosis (Mtb) is the causative agent of human tuberculosis (TB) which
primarily infects the macrophages. Nearly a quarter of the world's population is infected …
primarily infects the macrophages. Nearly a quarter of the world's population is infected …
ESX secretion systems: mycobacterial evolution to counter host immunity
MI Gröschel, F Sayes, R Simeone, L Majlessi… - Nature Reviews …, 2016 - nature.com
Mycobacterium tuberculosis uses sophisticated secretion systems, named 6 kDa early
secretory antigenic target (ESAT6) protein family secretion (ESX) systems (also known as …
secretory antigenic target (ESAT6) protein family secretion (ESX) systems (also known as …
A new evolutionary scenario for the Mycobacterium tuberculosis complex
The distribution of 20 variable regions resulting from insertion-deletion events in the
genomes of the tubercle bacilli has been evaluated in a total of 100 strains of …
genomes of the tubercle bacilli has been evaluated in a total of 100 strains of …
[HTML][HTML] M. tuberculosis and M. leprae translocate from the phagolysosome to the cytosol in myeloid cells
N van der Wel, D Hava, D Houben, D Fluitsma… - Cell, 2007 - cell.com
M. tuberculosis and M. leprae are considered to be prototypical intracellular pathogens that
have evolved strategies to enable growth in the intracellular phagosomes. In contrast, we …
have evolved strategies to enable growth in the intracellular phagosomes. In contrast, we …
ESX‐1‐mediated translocation to the cytosol controls virulence of mycobacteria
D Houben, C Demangel, J Van Ingen… - Cellular …, 2012 - Wiley Online Library
Mycobacterium species, including Mycobacterium tuberculosis and Mycobacterium leprae,
are among the most potent human bacterial pathogens. The discovery of cytosolic …
are among the most potent human bacterial pathogens. The discovery of cytosolic …
Specific immune-based diagnosis of tuberculosis
Current diagnostic tests for tuberculosis based on tuberculin have poor specificity, and both
BCG vaccination and exposure to non-tuberculosis mycobacteria produce a response …
BCG vaccination and exposure to non-tuberculosis mycobacteria produce a response …
The complete genome sequence of Mycobacterium bovis
T Garnier, K Eiglmeier, JC Camus, N Medina… - Proceedings of the …, 2003 - pnas.org
Mycobacterium bovis is the causative agent of tuberculosis in a range of animal species and
man, with worldwide annual losses to agriculture of $3 billion. The human burden of …
man, with worldwide annual losses to agriculture of $3 billion. The human burden of …
Type VII secretion—mycobacteria show the way
Recent evidence shows that mycobacteria have developed novel and specialized secretion
systems for the transport of extracellular proteins across their hydrophobic, and highly …
systems for the transport of extracellular proteins across their hydrophobic, and highly …
Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti
Although large human populations have been safely immunized against tuberculosis with
two live vaccines, Mycobacterium bovis BCG or Mycobacterium microti, the vole bacillus, the …
two live vaccines, Mycobacterium bovis BCG or Mycobacterium microti, the vole bacillus, the …
Genomic insights into tuberculosis
JE Galagan - Nature Reviews Genetics, 2014 - nature.com
Prevalent since pre-history, human tuberculosis—caused by the pathogen Mycobacterium
tuberculosis—remains a major source of death worldwide. Moreover, increasing drug …
tuberculosis—remains a major source of death worldwide. Moreover, increasing drug …