[HTML][HTML] The different autophagy degradation pathways and neurodegeneration

A Fleming, M Bourdenx, M Fujimaki, C Karabiyik… - Neuron, 2022‏ - cell.com
The term autophagy encompasses different pathways that route cytoplasmic material to
lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy …

A synaptic perspective of fragile X syndrome and autism spectrum disorders

C Bagni, RS Zukin - Neuron, 2019‏ - cell.com
Altered synaptic structure and function is a major hallmark of fragile X syndrome (FXS),
autism spectrum disorders (ASDs), and other intellectual disabilities (IDs), which are …

A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies

Y Kang, Y Zhou, Y Li, Y Han, J Xu, W Niu, Z Li… - Nature …, 2021‏ - nature.com
Fragile X syndrome (FXS) is caused by the loss of fragile X mental retardation protein
(FMRP), an RNA-binding protein that can regulate the translation of specific mRNAs. In this …

mTOR signaling disruption and its association with the development of autism spectrum disorder

SD Thomas, NK Jha, S Ojha, B Sadek - Molecules, 2023‏ - mdpi.com
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized
by impairments in social interaction and communication along with repetitive stereotypic …

ERK/MAPK signalling in the develo** brain: Perturbations and consequences

JD Iroegbu, OK Ijomone, OM Femi-Akinlosotu… - Neuroscience & …, 2021‏ - Elsevier
The extracellular regulated kinase/microtubule-associated protein kinase (ERK/MAPK)
signalling pathway transduces signals that cause an alteration in the ongoing metabolic …

[HTML][HTML] Molecular neurobiology of mTOR

K Switon, K Kotulska, A Janusz-Kaminska… - Neuroscience, 2017‏ - Elsevier
Mammalian/mechanistic target of rapamycin (mTOR) is a serine-threonine kinase that
controls several important aspects of mammalian cell function. mTOR activity is modulated …

Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders

R Gao, P Penzes - Current molecular medicine, 2015‏ - ingentaconnect.com
Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with
complex genetic architectures but overlap** behavioral phenotypes, which suggests …

Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations

ZX Xu, GH Kim, JW Tan, AE Riso, Y Sun, EY Xu… - Nature …, 2020‏ - nature.com
Mutations that inactivate negative translation regulators cause autism spectrum disorders
(ASD), which predominantly affect males and exhibit social interaction and communication …

Autism-related deficits via dysregulated eIF4E-dependent translational control

CG Gkogkas, A Khoutorsky, I Ran, E Rampakakis… - Nature, 2013‏ - nature.com
Hyperconnectivity of neuronal circuits due to increased synaptic protein synthesis is thought
to cause autism spectrum disorders (ASDs). The mammalian target of rapamycin (mTOR) is …

Fragile X syndrome

RJ Hagerman, E Berry-Kravis, HC Hazlett… - Nature reviews Disease …, 2017‏ - nature.com
Fragile X syndrome (FXS) is the leading inherited form of intellectual disability and autism
spectrum disorder, and patients can present with severe behavioural alterations, including …