Cholinergic Modulation of Sensory Perception and Plasticity
Sensory systems are highly plastic, but the mechanisms of sensory plasticity remain unclear.
People with vision or hearing loss demonstrate significant neural network reorganization …
People with vision or hearing loss demonstrate significant neural network reorganization …
Model-Based approaches to investigating mismatch responses in schizophrenia
Alterations of mismatch responses (ie, neural activity evoked by unexpected stimuli) are
often considered a potential biomarker of schizophrenia. Going beyond establishing the type …
often considered a potential biomarker of schizophrenia. Going beyond establishing the type …
EEG mismatch responses in a multimodal roving stimulus paradigm provide evidence for probabilistic inference across audition, somatosensation, and vision
The human brain is constantly subjected to a multimodal stream of probabilistic sensory
inputs. Electroencephalography (EEG) signatures, such as the mismatch negativity (MMN) …
inputs. Electroencephalography (EEG) signatures, such as the mismatch negativity (MMN) …
Sensitivity of schizophrenia endophenotype biomarkers to anticholinergic medication burden
YB Joshi, JL Molina, DL Braff… - American Journal of …, 2023 - Am Psychiatric Assoc
Methods Participants in the COGS-2 study have previously been described, including
inclusion and exclusion criteria (29). Participants were either healthy control subjects (HCS …
inclusion and exclusion criteria (29). Participants were either healthy control subjects (HCS …
[HTML][HTML] Aberrant hierarchical prediction errors are associated with transition to psychosis: a computational single-trial analysis of the mismatch negativity
Background Mismatch negativity reductions are among the most reliable biomarkers for
schizophrenia and have been associated with increased risk for conversion to psychosis in …
schizophrenia and have been associated with increased risk for conversion to psychosis in …
Predicting treatment response to ketamine in treatment-resistant depression using auditory mismatch negativity: Study protocol
J Martin, F Gholamali Nezhad, A Rueda, GH Lee… - Plos one, 2024 - journals.plos.org
Background Ketamine has recently attracted considerable attention for its rapid effects on
patients with major depressive disorder, including treatment-resistant depression (TRD) …
patients with major depressive disorder, including treatment-resistant depression (TRD) …
Circadian rhythms in auditory hallucinations and psychosis
Circadian rhythms are imprinted in all organisms and influence virtually all aspects of
physiology and behavior in adaptation to the 24‐h day–night cycle. This recognition of a …
physiology and behavior in adaptation to the 24‐h day–night cycle. This recognition of a …
Psychosis as a disorder of muscarinic signalling: psychopathology and pharmacology
Dopaminergic receptor antagonism is a crucial component of all licensed treatments for
psychosis, and dopamine dysfunction has been central to pathophysiological models of …
psychosis, and dopamine dysfunction has been central to pathophysiological models of …
Markers of muscarinic deficit for individualized treatment in schizophrenia
H Stuke - Frontiers in Psychiatry, 2023 - frontiersin.org
Recent clinical studies have shown that agonists at muscarinic acetylcholine receptors
effectively reduce schizophrenia symptoms. It is thus conceivable that, for the first time, a …
effectively reduce schizophrenia symptoms. It is thus conceivable that, for the first time, a …
M2 receptors are required for spatiotemporal sequence learning in mouse primary visual cortex
S Sarkar, C Martinez Reyes… - Journal of …, 2024 - journals.physiology.org
Acetylcholine is a neurotransmitter that plays a variety of roles in the central nervous system.
It was previously shown that blocking muscarinic receptors with a nonselective antagonist …
It was previously shown that blocking muscarinic receptors with a nonselective antagonist …