Most mammalian genes have multiple polyA sites, representing a substantial source of
transcript diversity regulated by the cleavage and polyadenylation (CPA) machinery. To …

O-methylation (Nm) is a prominent RNA modification well known in noncoding RNAs and
more recently also found at many mRNA internal sites. However, their function and base …

The 3′ untranslated region (3′ UTR) of mRNA plays a key role in the post-transcriptional
regulation of gene expression. Most eukaryotic protein-coding genes express 3′ UTR …

Cleavage and polyadenylation specificity factor subunit 6 (CPSF6, also known as CFIm68)
is a 68 kDa component of the mammalian cleavage factor I (CFIm) complex that modulates …

Nervous system development is associated with extensive regulation of alternative splicing
(AS) and alternative polyadenylation (APA). AS and APA have been extensively studied in …

Differential polyadenylation sites (PAs) critically regulate gene expression, but their cell type–
specific usage and spatial distribution in the brain have not been systematically …

Purpose Gliomas and their surrounding microenvironment constantly interact to promote
tumorigenicity, yet the underlying posttranscriptional regulatory mechanisms that govern this …

Acute myeloid leukemia (AML) with retinoic acid receptor gamma (RARG) fusions, which
exhibits clinical features resembling acute promyelocytic leukemia (APL), has been …

Nuclear depletion and cytoplasmic aggregation of the RNA-binding protein TDP-43 is the
hallmark of ALS, occurring in over 97% of cases. A key consequence of TDP-43 nuclear loss …

Genetic variants are involved in the orchestration of alternative polyadenylation (APA)
events, while the role of DNA methylation in regulating APA remains unclear. We generated …