Type VII secretion systems: structure, functions and transport models

A Rivera-Calzada, N Famelis, O Llorca… - Nature Reviews …, 2021 - nature.com
Type VII secretion systems (T7SSs) have a key role in the secretion of effector proteins in
non-pathogenic mycobacteria and pathogenic mycobacteria such as Mycobacterium …

The Type VII Secretion System of Staphylococcus

L Bowman, T Palmer - Annual review of microbiology, 2021 - annualreviews.org
The type VII protein secretion system (T7SS) of Staphylococcus aureus is encoded at the
ess locus. T7 substrate recognition and protein transport are mediated by EssC, a …

Plant commensal type VII secretion system causes iron leakage from roots to promote colonization

Y Liu, X Shu, L Chen, H Zhang, H Feng, X Sun… - Nature …, 2023 - nature.com
Competition for iron is an important factor for microbial niche establishment in the
rhizosphere. Pathogenic and beneficial symbiotic bacteria use various secretion systems to …

The type VII secretion system of Staphylococcus aureus secretes a nuclease toxin that targets competitor bacteria

Z Cao, MG Casabona, H Kneuper, JD Chalmers… - Nature …, 2016 - nature.com
The type VII protein secretion system (T7SS) plays a critical role in the virulence of human
pathogens including Mycobacterium tuberculosis and Staphylococcus aureus. Here, we …

A broadly distributed toxin family mediates contact-dependent antagonism between gram-positive bacteria

JC Whitney, SB Peterson, J Kim, M Pazos, AJ Verster… - Elife, 2017 - elifesciences.org
The Firmicutes are a phylum of bacteria that dominate numerous polymicrobial habitats of
importance to human health and industry. Although these communities are often densely …

The twin-arginine protein translocation pathway

BC Berks - Annual review of biochemistry, 2015 - annualreviews.org
The twin-arginine translocation (Tat) system, found in prokaryotes, chloroplasts, and some
mitochondria, allows folded proteins to be moved across membranes. How this transport is …

Tat-Independent Secretion of Polyethylene Terephthalate Hydrolase PETase in Bacillus subtilis 168 Mediated by Its Native Signal Peptide

X Huang, L Cao, Z Qin, S Li, W Kong… - Journal of agricultural …, 2018 - ACS Publications
Widespread utilization of polyethylene terephthalate (PET) has caused critical
environmental pollution. The enzymatic degradation of PET is a promising solution to this …

Substrates control multimerization and activation of the multi-domain ATPase motor of type VII secretion

OS Rosenberg, D Dovala, X Li, L Connolly… - Cell, 2015 - cell.com
Mycobacterium tuberculosis and Staphylococcus aureus secrete virulence factors via type
VII protein secretion (T7S), a system that intriguingly requires all of its secretion substrates …

The structure of the endogenous ESX-3 secretion system

N Poweleit, N Czudnochowski, R Nakagawa… - Elife, 2019 - elifesciences.org
The ESX (or Type VII) secretion systems are protein export systems in mycobacteria and
many Gram-positive bacteria that mediate a broad range of functions including virulence …

The antibacterial type VII secretion system of Bacillus subtilis: structure and interactions of the pseudokinase YukC/EssB

M Tassinari, T Doan, M Bellinzoni, M Chabalier… - MBio, 2022 - journals.asm.org
Type VIIb secretion systems (T7SSb) were recently proposed to mediate different aspects of
Firmicutes physiology, including bacterial pathogenicity and competition. However, their …