The genus Mycobacterium contains several slow-growing human pathogens, including
Mycobacterium tuberculosis, Mycobacterium leprae, and Mycobacterium avium …

The discovery of novel small-molecule antibacterial drugs has been stalled for many years.
The purpose of this review is to underscore and illustrate those scientific problems unique to …

Antibacterial agents target the products of essential genes but rarely achieve complete
target inhibition. Thus, the all-or-none definition of essentiality afforded by traditional genetic …

Generalist and specialist species differ in the breadth of their ecological niches. Little is
known about the niche width of obligate human pathogens. Here we analyzed a global …

As a result of an error during film output, Table 1 was published with some symbols missing.
The correct version can be found at http://www. sanger. ac. uk and is reproduced again here …

As centuries and millennia passed, human beings began to live in larger and larger
communities, and with this shift came environmental changes that were associated with a …

Global TB control efforts have been severely hampered by the lack of diagnostic tests that
are accurate, simple to use and can be applied at the point of clinical care. This has been …

Tuberculosis (TB), one of the oldest known human diseases. is still is one of the major
causes of mortality, since two million people die each year from this malady. TB has many …

One of the first issues that emerges when a prokaryotic organism of interest is encountered
is the question of what it is—that is, which species it is. The 16S rRNA gene formed the basis …

The distribution of 20 variable regions resulting from insertion-deletion events in the
genomes of the tubercle bacilli has been evaluated in a total of 100 strains of …