Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number
of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating …

Adult hippocampal neurogenesis is the process by which new functional neurons are added
to the adult dentate gyrus of the hippocampus. Animal studies have shown that the degree of …

Increasing evidence demonstrates that neuroplasticity, a fundamental mechanism of
neuronal adaptation, is disrupted in mood disorders and in animal models of stress. Here we …

Adult neurogenesis is the process by which new neurons are generated in the brains of
adults. Since its discovery 50 years ago, adult neurogenesis has been widely studied in the …

BACKGROUND: Adult neurogenesis occurs throughout life in discrete regions of the
mammalian brain and is tightly regulated via both extrinsic environmental influences and …

Recent clinical studies demonstrate that serum levels of brain-derived neurotrophic factor
(BDNF) are significantly decreased in patients with major depressive disorder (MDD) and …

Preclinical and clinical studies have demonstrated that stress or depression can lead to
atrophy and cell loss in limbic brain structures that are critically involved in depression …

The purpose of this review is to integrate what is currently known about the role of brain-
derived neurotrophic factor (BDNF) in the pathophysiology of mood disorders including …

Activity-regulated gene expression is believed to play a key role in the development and
refinement of neuronal circuitry. Nevertheless, the transcriptional networks that regulate …

Basic research in rodents has demonstrated that exposure to stress decreases levels of
brain-derived neurotrophic factor (BDNF) in brain regions associated with depression. In …