Proteins that self-assemble into polyhedral shell-like structures are useful molecular
containers both in nature and in the laboratory. Here we review efforts to repurpose diverse …

Precision medicine holds great promise to harness genetic and epigenetic cues for targeted
treatment of a variety of diseases, ranging from many types of cancers, neurodegenerative …

In the past 15 years, there have been rapid developments in the ability to cotranslationally
incorporate unnatural amino acids into proteins produced in cells, both at defined sites via …

The delivery of nucleic acids with transient activity for genetic engineering is a promising
methodology with potential applications in the treatment of diseases ranging from cancer …

(5aR, 11bS)-4, 5, 5a, 6, 7, 11b-Hexahydro-2-propyl-3-thia-5-azacyclopent-1-ena [c]
phenanthrene-9, 10-diol (A-86929): a potent and selective dopamine D1 agonist that …

Most drug therapies distribute the agents throughout the entire body, even though the drugs
are typically only needed at specific tissues. This often limits dosage and causes discomfort …

Virus-like particles (VLPs) are non-infectious self-assembling nanoparticles, useful in
medicine and nanotechnology. Their repetitive molecularly-defined architecture is attractive …

Aptamers are a class of small nucleic acid ligands that are composed of RNA or single-
stranded DNA oligonucleotides and have high specificity and affinity for their targets. Similar …

Synthetic carriers such as polymer and lipid particles often struggle to meet clinical
expectations. Natural particulates—that range from pathogens to mammalian cells—are …

Advances in genetic engineering tools have contributed to the development of strategies for
utilizing biologically derived vesicles as nanomedicines for achieving cell-specific drug …