Metabolic syndrome (MetS) is a complex hereditary condition comprising various metabolic
traits as risk factors. Although the genetics of individual MetS components have been …

The pathogenesis and clinical heterogeneity of Parkinson's disease (PD) have been
evaluated from molecular, pathophysiological, and clinical perspectives. High-throughput …

Summary Background As aortic aneurysms (AAs) enlarge, they can become life-threatening
if left undiagnosed or neglected. At present, there is a lack of radical treatments for …

A long-standing recognition that information from human genetics studies has the potential
to accelerate drug discovery has led to decades of research on how to leverage genetic and …

Parkinson's disease is highly heterogeneous across disease symptoms, clinical
manifestations and progression trajectories, hampering the identification of therapeutic …

Introduction Rheumatoid arthritis (RA) is a chronic inflammatory illness that mostly affects the
joints of the hands and feet and can reduce life expectancy by an average of 3 to 10 years …

Genome‑wide association studies (GWASs) have revealed numerous loci associated with
Parkinson's disease (PD). However, some potential causal/risk genes were still not revealed …

Immune system and blood–brain barrier dysfunction are implicated in the development of
Alzheimer's and other dementia-causing diseases, but their causal role remains unknown …

Introduction Migraine, as a complex neurological disease, brings heavy burden to patients
and society. Despite the availability of established therapies, existing medications have …

Current research lacks comprehensive investigations into the potential causal link between
mitochondrial-related genes and the risk of neurodegenerative diseases (NDDs). We aimed …