[HTML][HTML] Advances in the evolutionary understanding of MHC polymorphism
Proteins encoded by the classical major histocompatibility complex (MHC) genes incite the
vertebrate adaptive immune response by presenting peptide antigens on the cell surface …
vertebrate adaptive immune response by presenting peptide antigens on the cell surface …
Understanding the evolution of immune genes in jawed vertebrates
Driven by co‐evolution with pathogens, host immunity continuously adapts to optimize
defence against pathogens within a given environment. Recent advances in genetics …
defence against pathogens within a given environment. Recent advances in genetics …
Immunogenetic novelty confers a selective advantage in host–pathogen coevolution
The major histocompatibility complex (MHC) is crucial to the adaptive immune response of
vertebrates and is among the most polymorphic gene families known. Its high diversity is …
vertebrates and is among the most polymorphic gene families known. Its high diversity is …
HLA heterozygote advantage against HIV-1 is driven by quantitative and qualitative differences in HLA allele-specific peptide presentation
Pathogen-mediated balancing selection is regarded as a key driver of host immunogenetic
diversity. A hallmark for balancing selection in humans is the heterozygote advantage at …
diversity. A hallmark for balancing selection in humans is the heterozygote advantage at …
Ecological factors and morphological traits are associated with repeated genomic differentiation between lake and stream stickleback
The repeated evolution of similar phenotypes in independent populations (ie parallel or
convergent evolution) provides an opportunity to identify genetic and ecological factors that …
convergent evolution) provides an opportunity to identify genetic and ecological factors that …
Gene expression contributes to the recent evolution of host resistance in a model host parasite system
Heritable population differences in immune gene expression following infection can reveal
mechanisms of host immune evolution. We compared gene expression in infected and …
mechanisms of host immune evolution. We compared gene expression in infected and …
Scale‐dependent effects of host patch traits on species composition in a stickleback parasite metacommunity
A core goal of ecology is to understand the abiotic and biotic variables that regulate species
distributions and community composition. A major obstacle is that the rules governing …
distributions and community composition. A major obstacle is that the rules governing …
Host patch traits have scale‐dependent effects on diversity in a stickleback parasite metacommunity
Many metacommunities are distributed across habitat patches that are themselves
aggregated into groups. Perhaps the clearest example of this nested metacommunity …
aggregated into groups. Perhaps the clearest example of this nested metacommunity …
Population-level variation in parasite resistance due to differences in immune initiation and rate of response
Closely related populations often differ in resistance to a given parasite, as measured by
infection success or failure. Yet, the immunological mechanisms of these evolved …
infection success or failure. Yet, the immunological mechanisms of these evolved …
Divergent and non-parallel evolution of MHC IIB in the Neotropical Midas cichlid species complex
SE Bracamonte, MJ Hofmann, C Lozano-Martín… - BMC Ecology and …, 2022 - Springer
Background Ecological diversification is the result of divergent natural selection by
contrasting habitat characteristics that favours the evolution of distinct phenotypes. This …
contrasting habitat characteristics that favours the evolution of distinct phenotypes. This …