Primary liver cancer is the second leading cause of cancer-related death worldwide and
therefore a major public health challenge. We review hypotheses of the cell of origin of liver …

Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

The liver is a central organ for homeostasis with unique regenerative capacities. Mature
hepatocytes possess a remarkable capacity to proliferate upon injury, challenging efforts to …

The MET oncogene encodes an unconventional receptor tyrosine kinase with pleiotropic
functions: it initiates and sustains neoplastic transformation when genetically altered …

During the past decade, research on primary liver cancers has particularly highlighted the
uncommon plasticity of differentiated parenchymal liver cells (that is, hepatocytes and …

Abstract The Epidermal Growth Factor Receptor (EGFR) is frequently expressed at elevated
levels in different forms of cancer and expression often correlates positively with cancer …

The epidermal growth factor receptor (EGFR) is a transmembrane receptor tyrosine kinase
that is activated by several ligands leading to the activation of diverse signaling pathways …

Background & Aims Currently, much effort is directed towards the development of new cell
sources for clinical therapy using cell fate conversion by small molecules. Direct lineage …

Abstract Background and Aims Biliary atresia is a severe inflammatory and fibrosing
cholangiopathy of neonates of unknown etiology. The onset of cholestasis at birth implies a …

Techniques for reprogramming somatic cells create new opportunities for drug screening,
disease modeling, artificial organ development, and cell therapy. The development of …