Advanced imaging techniques for studying protein phase separation in living cells and at single-molecule level
Protein-protein and protein-RNA interactions are essential for cell function and survival.
These interactions facilitate the formation of ribonucleoprotein complexes and biomolecular …
These interactions facilitate the formation of ribonucleoprotein complexes and biomolecular …
Fluorescence Microscopy: a statistics-optics perspective
Fundamental properties of light unavoidably impose features on images collected using
fluorescence microscopes. Accounting for these features is often critical in quantitatively …
fluorescence microscopes. Accounting for these features is often critical in quantitatively …
Quantifying microsecond solution-phase conformational dynamics of a DNA hairpin at the single-molecule level
Quantifying the rapid conformational dynamics of biological systems is fundamental to
understanding the mechanism. However, biomolecules are complex, often containing static …
understanding the mechanism. However, biomolecules are complex, often containing static …
[HTML][HTML] Current Opinion in Chemical Biology: Issue: Chemical Biology of Protein Aggregation and phase separation
Protein-protein and protein-RNA interactions are essential for cell function and survival.
These interactions facilitate the formation of ribonucleoprotein (RNP) complexes and …
These interactions facilitate the formation of ribonucleoprotein (RNP) complexes and …
ALS/FTLD-Linked Mutant FUS Oligomerization in Cells
NA Djaja - 2024 - jscholarship.library.jhu.edu
Fused in sarcoma (FUS) is a nuclear RNA-binding protein (RBP) implicated in amyotrophic
lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD). FUS plays essential roles …
lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD). FUS plays essential roles …