DNA synthesis technologies to close the gene writing gap

A Hoose, R Vellacott, M Storch, PS Freemont… - Nature Reviews …, 2023 - nature.com
Synthetic DNA is of increasing demand across many sectors of research and commercial
activities. Engineering biology, therapy, data storage and nanotechnology are set for rapid …

Emerging approaches to DNA data storage: challenges and prospects

A Doricchi, CM Platnich, A Gimpel, F Horn, M Earle… - ACS …, 2022 - ACS Publications
With the total amount of worldwide data skyrocketing, the global data storage demand is
predicted to grow to 1.75× 1014 GB by 2025. Traditional storage methods have difficulties …

[HTML][HTML] Organoid intelligence (OI): the new frontier in biocomputing and intelligence-in-a-dish

L Smirnova, BS Caffo, DH Gracias, Q Huang… - Frontiers in …, 2023 - frontiersin.org
Recent advances in human stem cell-derived brain organoids promise to replicate critical
molecular and cellular aspects of learning and memory and possibly aspects of cognition in …

High-throughput DNA synthesis for data storage

M Yu, X Tang, Z Li, W Wang, S Wang, M Li… - Chemical Society …, 2024 - pubs.rsc.org
With the explosion of digital world, the dramatically increasing data volume is expected to
reach 175 ZB (1 ZB= 1012 GB) in 2025. Storing such huge global data would consume tons …

Recent progress in non-native nucleic acid modifications

LK McKenzie, R El-Khoury, JD Thorpe… - Chemical Society …, 2021 - pubs.rsc.org
While Nature harnesses RNA and DNA to store, read and write genetic information, the
inherent programmability, synthetic accessibility and wide functionality of these nucleic acids …

Modern approaches to therapeutic oligonucleotide manufacturing

R Obexer, M Nassir, ER Moody, PS Baran, SL Lovelock - Science, 2024 - science.org
Therapeutic oligonucleotides are a powerful drug modality with the potential to treat many
diseases. The rapidly growing number of therapies that have been approved and that are in …

Expanding chemistry through in vitro and in vivo biocatalysis

EN Kissman, MB Sosa, DC Millar, EJ Koleski… - Nature, 2024 - nature.com
Living systems contain a vast network of metabolic reactions, providing a wealth of enzymes
and cells as potential biocatalysts for chemical processes. The properties of protein and cell …

Data storage using DNA

S Wang, X Mao, F Wang, X Zuo, C Fan - Advanced Materials, 2024 - Wiley Online Library
The exponential growth of global data has outpaced the storage capacities of current
technologies, necessitating innovative storage strategies. DNA, as a natural medium for …

Synthetic DNA applications in information technology

LC Meiser, BH Nguyen, YJ Chen, J Nivala… - Nature …, 2022 - nature.com
Synthetic DNA is a growing alternative to electronic-based technologies in fields such as
data storage, product tagging, or signal processing. Its value lies in its characteristic …

Random access DNA memory using Boolean search in an archival file storage system

JL Banal, TR Shepherd, J Berleant, H Huang… - Nature materials, 2021 - nature.com
DNA is an ultrahigh-density storage medium that could meet exponentially growing
worldwide demand for archival data storage if DNA synthesis costs declined sufficiently and …