Glial polarization in neurological diseases: molecular mechanisms and therapeutic opportunities
Glial cell polarization plays a pivotal role in various neurological disorders. In response to
distinct stimuli, glial cells undergo polarization to either mitigate neurotoxicity or facilitate …
distinct stimuli, glial cells undergo polarization to either mitigate neurotoxicity or facilitate …
Therapeutic Targeting of Krüppel-Like Factor 4 and Its Pharmacological Potential in Parkinson's Disease: A Comprehensive Review
Krüppel-like factor 4 (KLF4), a zinc finger transcription factor, is found in different human
tissues and shows diverse regulatory activities in a cell-dependent manner. In the brain …
tissues and shows diverse regulatory activities in a cell-dependent manner. In the brain …
[HTML][HTML] Quercetin improves cerebral ischemia/reperfusion injury by promoting microglia/macrophages M2 polarization via regulating PI3K/Akt/NF-κB signaling …
L Li, W Jiang, B Yu, H Liang, S Mao, X Hu… - Biomedicine & …, 2023 - Elsevier
The modulation of microglial polarization from the pro-inflammatory M1 to the anti-
inflammatory M2 phenotype shows promise as a therapeutic strategy for ischemic stroke …
inflammatory M2 phenotype shows promise as a therapeutic strategy for ischemic stroke …
A dual synergetic nanoreactor for managing parkinson's disease by regulating inflammation and mitigating oxidative damage
Q Li, T Wu, OU Akakuru, N Song, W Liu… - Advanced Functional …, 2023 - Wiley Online Library
Glial cell‐dominated inflammatory microenvironment and neuronal damage due to oxidative
stress are major impediments to the treatment of central nervous degenerative diseases …
stress are major impediments to the treatment of central nervous degenerative diseases …
Lapatinib ditosylate rescues motor deficits in rotenone-intoxicated rats: Potential repurposing of anti-cancer drug as a disease-modifying agent in Parkinson's disease
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor deficits
induced by dopaminergic neuronal death in the substantia nigra (SN). Finding a successful …
induced by dopaminergic neuronal death in the substantia nigra (SN). Finding a successful …
The critical role of KLF4 in regulating the activation of A1/A2 reactive astrocytes following ischemic stroke
C Wang, L Li - Journal of Neuroinflammation, 2023 - Springer
Background We have previously demonstrated that the expression of kruppel-like
transcription factor-4 (KLF-4) is upregulated in astrocytes following acute ischemic stroke …
transcription factor-4 (KLF-4) is upregulated in astrocytes following acute ischemic stroke …
Pazopanib ameliorates rotenone-induced Parkinsonism in rats by suppressing multiple regulated cell death mechanisms
Parkinson's disease (PD) is characterized by motor impairments and progressive
dopaminergic neuronal death in the substantia nigra (SN). Recently, the involvement of …
dopaminergic neuronal death in the substantia nigra (SN). Recently, the involvement of …
Non-coding RNA in microglia activation and neuroinflammation in Alzheimer's disease
C He, Z Li, M Yang, W Yu, R Luo, J Zhou… - Journal of …, 2023 - Taylor & Francis
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by complex
pathophysiological features. Amyloid plaques resulting from extracellular amyloid deposition …
pathophysiological features. Amyloid plaques resulting from extracellular amyloid deposition …
Xanthotoxin modulates oxidative stress, inflammation, and MAPK signaling in a rotenone-induced Parkinson's disease model
Aims Parkinson's disease (PD) is characterized by motor disabilities precipitated by α-
synuclein aggregation and dopaminergic neurodegeneration. The roles of oxidative stress …
synuclein aggregation and dopaminergic neurodegeneration. The roles of oxidative stress …
Comparative pharmacodynamic study delineating the efficacy of amantadine loaded nano-emulsified organogel via intranasal versus transdermal route in rotenone …
Owing to the dysphagia and gastroparesis in patients concomitant with Parkinson's disease
(PD), oral amantadine (AMT) medications are susceptible to poor bioavailability and clinical …
(PD), oral amantadine (AMT) medications are susceptible to poor bioavailability and clinical …