The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …

Many transcription factors play a key role in cellular differentiation and the delineation of cell
phenotype. Transcription factors are regulated by phosphorylation, ubiquitination …

Forkhead box (FOX) proteins are multifaceted transcription factors that are responsible for
fine-tuning the spatial and temporal expression of a broad range of genes both during …

This review addresses the oncopharmacological properties of curcumin at the molecular
level. First, the interactions between curcumin and its molecular targets are addressed on …

Forkhead box O (FoxO) transcription factors are downstream targets of the serine/threonine
protein kinase B (PKB)/Akt. The Akt kinase regulates processes of cellular proliferation and …

One signal that is overactivated in a wide range of tumour types is the production of a
phospholipid, phosphatidylinositol (3, 4, 5) trisphosphate, by phosphatidylinositol 3-kinase …

Genistein is a soy derived isoflavanoid compound with multitude of health benefits. This
compound is found to be a potent agent in both prophylaxis and treatment of cancer and …

Extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) are members of the mitogen-
activated protein kinase super family that can mediate cell proliferation and apoptosis. The …

Abstract The PI3K/Akt signal transduction cascade has been investigated extensively for its
roles in oncogenic transformation. Initial studies implicated both PI3K and Akt in prevention …

Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …