Biased agonism (or “functional selectivity”) at G-protein-coupled receptors has attracted
rapidly increasing interest as a means to improve discovery of more efficacious and safer …

Gamma oscillations comprise a loosely defined, heterogeneous group of functionally
different activities between 30 and 100 Hz in the cortical and subcortical local field potential …

Symptomatic treatment options for Parkinson disease have steadily improved, and
individualized therapeutic approaches are becoming established for every stage of the …

Cortico-basal ganglia circuits are thought to play a crucial role in the selection and control of
motor behaviors and have also been implicated in the processing of motivational content …

Background Long-term treatment of Parkinson's disease (PD) with l-DOPA typically leads to
development of l-DOPA induced dyskinesia (LID). Amantadine, an NMDA antagonist …

Abstract L-DOPA-induced dyskinesia (LID) in Parkinson's disease has been linked to
oscillatory neuronal activities in the cortico-basal ganglia network. We set out to examine the …

Abstract l-DOPA is the gold-standard pharmacotherapy for treatment of Parkinson's disease
(PD) but can lead to the appearance of troubling dyskinesia which are attributable to 'false …

The mechanisms and significance of basal ganglia oscillations is a fundamental research
question engaging both clinical and basic investigators. In Parkinson's disease (PD), neural …

Oscillations are a naturally occurring phenomenon in highly interconnected dynamical
systems. However, it is thought that excessive synchronized oscillations in brain circuits can …

Serotonin 5-HT 1A receptor agonists are prime candidates for CNS drug discovery due to
their involvement physiological and pathological processes relevant to neurology and …