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CDK11, a splicing-associated kinase regulating gene expression
M Hluchý, D Blazek - Trends in Cell Biology, 2024 - cell.com
The ability of a cell to properly express its genes depends on optimal transcription and
splicing. RNA polymerase II (RNAPII) transcribes protein-coding genes and produces pre …
splicing. RNA polymerase II (RNAPII) transcribes protein-coding genes and produces pre …
Targeting RNA splicing modulation: new perspectives for anticancer strategy?
X Lv, X Sun, Y Gao, X Song, X Hu, L Gong… - Journal of Experimental …, 2025 - Springer
The excision of introns from pre-mRNA is a crucial process in the expression of the majority
of genes. Alternative splicing allows a single gene to generate diverse mRNA and protein …
of genes. Alternative splicing allows a single gene to generate diverse mRNA and protein …
Integrated analysis of single-cell RNA-seq and bulk RNA-seq reveals immune suppression subtypes and establishes a novel signature for determining the prognosis …
S Mao, Y Wang, N Chao, L Zeng, L Zhang - Cellular Oncology, 2024 - Springer
Background Lung adenocarcinoma (LUAD) is the most common histological type of lung
cancer with lower survival rates. Recent advancements in targeted therapies and …
cancer with lower survival rates. Recent advancements in targeted therapies and …
[HTML][HTML] Mode of action exploration for prostate epithelial cell injury caused by bisphenol A
B Liang, J Chen, L Wang, L Zhang, S Huang… - Ecotoxicology and …, 2024 - Elsevier
Bisphenol A (BPA) is a typical food chemical contaminant with various detrimental effects,
especially on reproductive system. Male prostate damage is also one of its major adverse …
especially on reproductive system. Male prostate damage is also one of its major adverse …
The development of α, β-unsaturated lactam-based andrographolide derivatives as anti-gastric cancer agents with the ability of inhibiting the ERK/c-Fos/Jun pathway
H Zhang, Z Xu, Z Xu, S Bian, N Qiao, X Wang… - European Journal of …, 2025 - Elsevier
Gastric cancer remains one of the global health threats for human beings. However, the
therapeutic efficacy of the widely-used chemotherapy is usually limited due to the lack of …
therapeutic efficacy of the widely-used chemotherapy is usually limited due to the lack of …
CPSF4-mediated regulation of alternative splicing of HMG20B facilitates the progression of triple-negative breast cancer
G Zhong, Q Shen, X Zheng, K Yu, H Lu, B Wei… - Journal of Translational …, 2024 - Springer
Background Aberrant alternative splicing (AS) contributes to tumor progression. A crucial
component of AS is cleavage and polyadenylation specificity factor 4 (CPSF4). It remains …
component of AS is cleavage and polyadenylation specificity factor 4 (CPSF4). It remains …
The role of BUD31 in clear cell renal cell carcinoma: prognostic significance, alternative splicing, and tumor immune environment
X Wu, R Fan, Y Zhang, C Duan, X Yao, K Liu… - Clinical and …, 2024 - Springer
BUD31, a splicing factor, is linked to various cancers. This study examines BUD31's
expression, prognostic value, mutation profile, genomic instability, tumor immune …
expression, prognostic value, mutation profile, genomic instability, tumor immune …
Sex-specific mRNA alternative splicing patterns and Dmrt1 isoforms contribute to sex determination and differentiation of oyster
L Guo, H Yu, Q Li - International Journal of Biological Macromolecules, 2024 - Elsevier
Alternative splicing (AS) of pre-mRNA is a crucial mechanism that regulates the expression
of genes involved in sex determination and differentiation. Despite its importance, AS has …
of genes involved in sex determination and differentiation. Despite its importance, AS has …
Exploring a new signature for lung adenocarcinoma: analyzing cuproptosis-related genes through Integrated single-cell and bulk RNA sequencing
J Liu, W **
countries, despite advances in screening and prevention. Novel therapeutic strategies are …
countries, despite advances in screening and prevention. Novel therapeutic strategies are …