The increasing utilization of heavy metals in modern industries leads to an increase in the
environmental burden. Nickel represents a good example of a metal whose use is widening …

Human exposure to highly nickel-polluted environments, such as those associated with
nickel refining, electroplating, and welding, has the potential to produce a variety of …

Occupational and environmental exposures to metals are associated with the development
of various cancers. Although carcinogenesis caused by metals has been intensively …

Many metals and metal-containing compounds have been identified to be potent mutagens
and carcinogens. Recently, a new sub-discipline of molecular toxicology and …

The past decade has seen an intense focus on mechanisms of apoptosis. Many important
observations on the various signaling pathways mediating apoptotic cell death have been …

Epidemiological evidence suggests that exposure to certain metals causes carcinogenesis.
The mechanisms of metal-induced carcinogenesis have been pursued in chemical …

Nickel is a widely distributed metal that is industrially applied in many forms. Accumulated
epidemiological evidence confirms that exposures to nickel compounds are associated with …

Epidemiological data indicate that exposure to metal and metalloid species, including
arsenic (III), chromium (VI), and nickel (II), increases the risk of cancer, particularly of the …

Nickel compounds are carcinogenic to humans, possibly through induction of reactive
oxygen species (ROS) that damage macromolecules including DNA and proteins. The aim …

High concentrations of nickel (Ni) are harmful to humans and animals. Ni targets a number
of organs and produces multiple toxic effects. Apoptosis is important in Ni-induced toxicity of …