Investigations of long-term changes in brain structure and function that accompany chronic
exposure to drugs of abuse suggest that alterations in gene regulation contribute …

Drug addiction involves potentially life-long behavioral abnormalities that are caused in
vulnerable individuals by repeated exposure to a drug of abuse. The persistence of these …

Primary somatosensory neurons are specialized to transmit specific types of sensory
information through differences in cell size, myelination, and the expression of distinct …

The nucleus accumbens is a key mediator of cocaine reward, but the distinct roles of the two
subpopulations of nucleus accumbens projection neurons, those expressing dopamine D1 …

Cocaine-induced alterations in gene expression cause changes in neuronal morphology
and behavior that may underlie cocaine addiction. In mice, we identified an essential role for …

Drugs of abuse elevate dopamine levels in the nucleus accumbens (NAc) and alter
transcriptional programs believed to promote long-lasting synaptic and behavioral …

Neurons are submitted to an exceptional variety of stimuli and are able to convert these into
high-order functions, such as storing memories, controlling behavior, and governing …

Despite the importance of numerous psychosocial factors, at its core, drug addiction involves
a biological process: the ability of repeated exposure to a drug of abuse to induce changes …

Decreased medial prefrontal cortex (mPFC) neuronal activity is associated with social defeat-
induced depression-and anxiety-like behaviors in mice. However, the molecular …

Over the past decade, it has become increasingly obvious that epigenetic mechanisms are
an integral part of a multitude of brain functions that range from the development of the …