Degradable polyprodrugs: design and therapeutic efficiency
Prodrugs are developed to increase the therapeutic properties of drugs and reduce their
side effects. Polyprodrugs emerged as highly efficient prodrugs produced by the …
side effects. Polyprodrugs emerged as highly efficient prodrugs produced by the …
Molecular basis and rationale for combining immune checkpoint inhibitors with chemotherapy in non-small cell lung cancer
Immunotherapy has prompted a paradigm shift in advanced non-small cell lung cancer
(NSCLC) treatment, by demonstrating superior efficacy to chemotherapy alone both in …
(NSCLC) treatment, by demonstrating superior efficacy to chemotherapy alone both in …
High‐Load Gemcitabine Inorganic–Organic Hybrid Nanoparticles as an Image‐Guided Tumor‐Selective Drug‐Delivery System to Treat Pancreatic Cancer
M Ischyropoulou, K Sabljo, L Schneider… - Advanced …, 2023 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDAC) has a devastating prognosis without effective
treatment options. Thus, there is an urgent need for more effective and safe therapies. Here …
treatment options. Thus, there is an urgent need for more effective and safe therapies. Here …
Deoxycytidine release from pancreatic stellate cells promotes gemcitabine resistance
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer deaths in the
United States. The deoxynucleoside analogue gemcitabine is among the most effective …
United States. The deoxynucleoside analogue gemcitabine is among the most effective …
[HTML][HTML] Role of drug catabolism, modulation of oncogenic signaling and tumor microenvironment in microbe-mediated pancreatic cancer chemoresistance
Pancreatic ductal adenocarcinoma (PDAC) has one of the highest incidence/death ratios
among all neoplasms due to its late diagnosis and dominant chemoresistance. Most PDAC …
among all neoplasms due to its late diagnosis and dominant chemoresistance. Most PDAC …
Single-organoid analysis reveals clinically relevant treatment-resistant and invasive subclones in pancreatic cancer
M Le Compte, EC De La Hoz, S Peeters… - NPJ Precision …, 2023 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal diseases, characterized
by a treatment-resistant and invasive nature. In line with these inherent aggressive …
by a treatment-resistant and invasive nature. In line with these inherent aggressive …
Comprehensive molecular characterization identifies distinct genomic and immune hallmarks of renal medullary carcinoma
Renal medullary carcinoma (RMC) is a highly lethal malignancy that mainly afflicts young
individuals of African descent and is resistant to all targeted agents used to treat other renal …
individuals of African descent and is resistant to all targeted agents used to treat other renal …
Multicenter prospective phase II trial of neoadjuvant dose-dense gemcitabine plus cisplatin in patients with muscle-invasive bladder cancer
G Iyer, AV Balar, MI Milowsky, BH Bochner… - Journal of clinical …, 2018 - ascopubs.org
Purpose Neoadjuvant chemotherapy followed by radical cystectomy (RC) is a standard of
care for the management of muscle-invasive bladder cancer (MIBC). Dose-dense cisplatin …
care for the management of muscle-invasive bladder cancer (MIBC). Dose-dense cisplatin …
Cell counting and viability assessment of 2D and 3D cell cultures: expected reliability of the trypan blue assay
Background Whatever the target of an experiment in cell biology, cell counting and viability
assessment are always computed. The Trypan Blue (TB) assay was proposed about a …
assessment are always computed. The Trypan Blue (TB) assay was proposed about a …
[HTML][HTML] Predictors of chemotherapy efficacy in non-small-cell lung cancer: a challenging landscape
Background Conventional cytotoxic chemotherapy (CCC) is the backbone of non-small-cell
lung cancer (NSCLC) treatment since decades and still represents a key element of the …
lung cancer (NSCLC) treatment since decades and still represents a key element of the …