Frailty, a critical intermediate status of the aging process that is at increased risk for negative
health-related events, includes physical, cognitive, and psychosocial domains or …

Alzheimer's disease (AD) is the most common form of dementia in the elderly followed by
vascular dementia. In addition to clinically diagnosed dementia, cognitive dysfunction has …

Insulin resistance is the main mechanism in a whole series of pathological conditions, which
are not only of metabolic interest but also of a systemic type. This phenomenon means that …

Although the brain has been considered an insulin-insensitive organ, recent reports on the
location of insulin and its receptors in the brain have introduced new ways of considering …

The search for treatments for neurodegenerative diseases is a major concern in light of
today's aging population and an increasing burden on individuals, families, and society …

Metabolic dysfunction is a well-established feature of Alzheimer's disease (AD), evidenced
by brain glucose hypometabolism that can be observed potentially decades prior to the …

Background Alzheimer's disease is the most prevalent cause of dementia in the elderly.
Neuronal death and synaptic dysfunctions are considered the main hallmarks of this …

Obesity mediates most of its direct medical sequelae through the development of insulin
resistance (IR). The cellular effects of insulin occur through two main postreceptor pathways …

Alzheimer disease (AD) is the most common form of dementia among the elderly and is
characterized by progressive loss of memory and cognition. Epidemiological data show that …

Background: Recent evidence has indicated that flavanol consumption may have many
health benefits in humans, including improved cognitive activities. Objective: The aim was to …