The dramatic global rise of MDR and XDR Enterobacterales in human medicine forced
clinicians to the reintroduction of colistin as last-resort drug. Meanwhile, colistin is used in …

For people living in developed countries life span is growing at a faster pace than ever. One
of the main reasons for such success is attributable to the introduction and extensive use in …

Multidrug-resistant (MDR) Klebsiella pneumoniae represents an increasing threat to human
health, causing difficult-to-treat infections with a high mortality rate. Since colistin is one of …

Until recently, the polymyxin antibiotics were used sparingly due to dose limiting toxicities.
However, the lack of therapeutic alternatives for infections caused by highly resistant Gram …

Objectives The β-lactam/β-lactamase inhibitor combination ceftazidime/avibactam is active
against KPC-producing Enterobacterales. Herein, we present molecular and phenotypic …

The emergence of genetic mutations in chromosomal genes and the transmissible plasmid-
mediated colistin resistance gene may have helped in the spread of colistin resistance …

Background Klebsiella pneumoniae is a major bacterial and opportunistic human pathogen,
increasingly recognized as a healthcare burden globally. The convergence of resistance …

The worldwide spread of carbapenem-and polymyxin-resistant Enterobacterales represents
an urgent public-health threat. However, for most countries in the Americas, the available …

Background: The resistance to colistin and carbapenems in Klebsiella pneumoniae
infections have been associated with increased morbidity and mortality worldwide. A …

Abstract Background Carbapenemase-producing Klebsiella pneumoniae has become a
global priority, not least in low-and middle-income countries. Here, we report the emergence …