Best practices for single-cell analysis across modalities
Recent advances in single-cell technologies have enabled high-throughput molecular
profiling of cells across modalities and locations. Single-cell transcriptomics data can now …
profiling of cells across modalities and locations. Single-cell transcriptomics data can now …
Graph representation learning in biomedicine and healthcare
Networks—or graphs—are universal descriptors of systems of interacting elements. In
biomedicine and healthcare, they can represent, for example, molecular interactions …
biomedicine and healthcare, they can represent, for example, molecular interactions …
[HTML][HTML] Organization of the human intestine at single-cell resolution
The intestine is a complex organ that promotes digestion, extracts nutrients, participates in
immune surveillance, maintains critical symbiotic relationships with microbiota and affects …
immune surveillance, maintains critical symbiotic relationships with microbiota and affects …
Spatially informed cell-type deconvolution for spatial transcriptomics
Many spatially resolved transcriptomic technologies do not have single-cell resolution but
measure the average gene expression for each spot from a mixture of cells of potentially …
measure the average gene expression for each spot from a mixture of cells of potentially …
Spatial components of molecular tissue biology
Methods for profiling RNA and protein expression in a spatially resolved manner are rapidly
evolving, making it possible to comprehensively characterize cells and tissues in health and …
evolving, making it possible to comprehensively characterize cells and tissues in health and …
Spatial omics and multiplexed imaging to explore cancer biology
Understanding intratumoral heterogeneity—the molecular variation among cells within a
tumor—promises to address outstanding questions in cancer biology and improve the …
tumor—promises to address outstanding questions in cancer biology and improve the …
Spatially informed clustering, integration, and deconvolution of spatial transcriptomics with GraphST
Spatial transcriptomics technologies generate gene expression profiles with spatial context,
requiring spatially informed analysis tools for three key tasks, spatial clustering, multisample …
requiring spatially informed analysis tools for three key tasks, spatial clustering, multisample …
Deciphering spatial domains from spatially resolved transcriptomics with an adaptive graph attention auto-encoder
Recent advances in spatially resolved transcriptomics have enabled comprehensive
measurements of gene expression patterns while retaining the spatial context of the tissue …
measurements of gene expression patterns while retaining the spatial context of the tissue …
Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays
Spatially resolved transcriptomic technologies are promising tools to study complex
biological processes such as mammalian embryogenesis. However, the imbalance between …
biological processes such as mammalian embryogenesis. However, the imbalance between …
SODB facilitates comprehensive exploration of spatial omics data
Spatial omics technologies generate wealthy but highly complex datasets. Here we present
Spatial Omics DataBase (SODB), a web-based platform providing both rich data resources …
Spatial Omics DataBase (SODB), a web-based platform providing both rich data resources …