Generating human hematopoietic stem cells (HSCs) from autologous tissues, when coupled
with genome editing technologies, is a promising approach for cellular transplantation …

Transfusion of red blood cells (RBCs) is a standard and indispensable therapy in current
clinical practice. In vitro production of RBCs offers a potential means to overcome a shortage …

In vitro RBC production from stem cells could represent an alternative to classic transfusion
products. Until now the clinical feasibility of this concept has not been demonstrated. We …

Blood‐transfusion centers regularly face the challenge of donor blood shortages, especially
for rare blood groups. The possibility of producing universal red blood cells from stem cells …

Abstract Sphingosine 1-phosphate (S1P) is an intercellular signaling molecule present in
blood. Erythrocytes have a central role in maintaining the S1P concentration in the blood …

Murine-based cellular models have provided and continue to provide many useful insights
into the fundamental mechanisms of erythropoiesis, as well as insights into the …

The ex vivo generation of human red blood cells on a large scale from hematopoietic stem
and progenitor cells has been considered as a potential method to overcome blood supply …

In the hematopoietic hierarchy, only stem cells are thought to be capable of long-term self-
renewal. Erythroid progenitors derived from fetal or adult mammalian hematopoietic tissues …

Highlights•Erythropoiesis entails a progressive reduction in mitochondria
content.•Mitochondria clearance is directed by distinct transcriptional programs.• …

Recent advances have increased excitement about the potential for therapeutic production
of red blood cells (RBCs) in vitro. However, generation of RBCs in the large numbers …