Leading compounds for the validation of animal models of psychopathology
V Micale, J Kucerova, A Sulcova - Cell and Tissue Research, 2013 - Springer
Modelling of complex psychiatric disorders, eg, depression and schizophrenia, in animals is
a major challenge, since they are characterized by certain disturbances in functions that are …
a major challenge, since they are characterized by certain disturbances in functions that are …
OBscure but not OBsolete: Perturbations of the frontal cortex in common between rodent olfactory bulbectomy model and major depression
R Rajkumar, GS Dawe - Journal of Chemical Neuroanatomy, 2018 - Elsevier
Olfactory bulbectomy (OBX) has been used as a model of depression over several decades.
This model presupposes a mechanism that is still not proven in clinical depression. A wealth …
This model presupposes a mechanism that is still not proven in clinical depression. A wealth …
Serotonin system gene polymorphisms are associated with impulsivity in a context dependent manner
Impulsivity is a risk factor for adverse outcomes and characterizes several psychiatric
disorders and risk for suicide. There is strong evidence that genetic variation influences …
disorders and risk for suicide. There is strong evidence that genetic variation influences …
Reappraisal of spontaneous stereotypy in the deer mouse as an animal model of obsessive-compulsive disorder (OCD): response to escitalopram treatment and …
Obsessive-compulsive disorder (OCD) is characterized by recurrent thoughts and repetitive
motor actions. Hyposerotonergic signalling in the cortico-striatal circuitry is believed to be …
motor actions. Hyposerotonergic signalling in the cortico-striatal circuitry is believed to be …
The effects of benzofury (5-APB) on the dopamine transporter and 5-HT2-dependent vasoconstriction in the rat
APB, commonly marketed as 'benzofury'is a new psychoactive substance and erstwhile
'legal high'which has been implicated in 10 recent drug-related deaths in the UK. This drug …
'legal high'which has been implicated in 10 recent drug-related deaths in the UK. This drug …
Effects of Subchronic Buspirone Treatment on Depressive Profile in Socially Isolated Rats: Implication of Early Life Experience on 5-HT1A Receptor-Related …
NS Tzeng, JY Chung, CC Lin, PY Cheng, YP Liu - Pharmaceuticals, 2024 - mdpi.com
The heterogeneity of etiology may serve as a crucial factor in the challenges of treatment,
including the low response rate and the delay in establishing therapeutic effect. In the …
including the low response rate and the delay in establishing therapeutic effect. In the …
Restoration of serotonin neuronal firing following long-term administration of bupropion but not paroxetine in olfactory bulbectomized rats
ME Mansari, S Manta, C Oosterhof… - International Journal …, 2015 - academic.oup.com
Background: Olfactory bulbectomized rats generally manifest many of the neurochemical,
physiological, and behavioral features of major depressive disorder in humans. Another …
physiological, and behavioral features of major depressive disorder in humans. Another …
Two weeks of buspirone protects against posthypoxic ventilatory pauses in the C57BL/6J mouse strain
MW Moore, S Chai, CB Gillombardo, A Carlo… - Respiratory physiology …, 2012 - Elsevier
The purpose was to determine if 2 weeks of buspirone suppressed post-hypoxic breathing
instability and pauses in the C57BL/6J (B6) mouse. Study groups were vehicle (saline, n …
instability and pauses in the C57BL/6J (B6) mouse. Study groups were vehicle (saline, n …
The effects of OB-induced depression on nociceptive behaviors induced by electrical stimulation of the dura mater surrounding the superior sagittal sinus
J Liang, S Yu, Z Dong, X Wang, R Liu, X Chen, Z Li - Brain research, 2011 - Elsevier
A bi-directional relationship between depression and migraine has been widely reported in
epidemiological and clinical studies, but the mechanisms of interaction between these …
epidemiological and clinical studies, but the mechanisms of interaction between these …
Chronic fluvoxamine treatment changes 5-HT2A/2C receptor-mediated behavior in olfactory bulbectomized mice
A Oba, O Nakagawasai, H Onogi, W Nemoto, F Yaoita… - Life sciences, 2013 - Elsevier
AIMS: Olfactory bulbectomy (OBX) in rodents represents a valuable experimental model of
depression. This study was designed to shed further light on the impact of putative …
depression. This study was designed to shed further light on the impact of putative …