Formalized rules for protein-protein interactions have recently been introduced to represent
the binding and enzymatic activities of proteins in cellular signaling. Rules encode an …

Accurate simulation of intracellular biochemical networks is essential to furthering our
understanding of biological system behavior. The number of protein complexes and of …

Computer simulations have become an invaluable tool to study the sometimes
counterintuitive temporal dynamics of (bio-) chemical systems. In particular, stochastic …

The study of the complex web of interactions that link biological molecules in a cell is the
subject of interactomics–currently one of the fastest moving fields in molecular biology. The …

Various persistent organic pollutants (POPs) including estrogens are often enriched in
mangrove regions. This research investigated the estrogens pollution levels in six …

The dynamics of molecular systems is an essential tool of systems biology. It helps figuring
out what is the effect of the perturbation of a system, or what is the best dose for a drug or …

Recent technological and theoretical advances are only now allowing the simulation of
detailed kinetic models of biological systems that reflect the stochastic movement and …

Noise biology focuses on the sources, processing, and biological consequences of the
inherent stochastic fluctuations in molecular transitions or interactions that control cellular …

In vitro enzyme reactions are traditionally conducted under conditions of pronounced
substrate excess since this guarantees that the bound enzyme is at quasi-steady-state …

Systems biology modeling of signal transduction pathways traditionally employs ordinary
differential equations, deterministic models based on the assumptions of spatial …