Multivalent proteins and nucleic acids, collectively referred to as multivalent associative
biomacromolecules, provide the driving forces for the formation and compositional …

The concept of phase-separation-mediated formation of biomolecular condensates provides
a new framework to understand cellular organization and cooperativity-dependent cellular …

Biomolecular condensate formation has been implicated in a host of biological processes
and has found relevance in biology and disease. Understanding the physical principles and …

We report the de novo design of small (< 20 kDa) and highly soluble synthetic intrinsically
disordered proteins (SynIDPs) that confer solubility to a fusion partner with minimal effect on …

Control of the electrochemical environment in living cells is typically attributed to ion
channels. Here, we show that the formation of biomolecular condensates can modulate the …

Biomolecular condensation is a key mechanism for organizing cellular processes in a
spatiotemporal manner. The phase-transition nature of this process defines a density …

Covalent polymers are versatile macromolecules that have found widespread use in society.
Contemporary methods of polymerization have made it possible to construct sequence …

Biomolecular condensation via liquid–liquid phase separation (LLPS) of intrinsically
disordered proteins/regions (IDPs/IDRs), with and without nucleic acids, has drawn …

Sequence-ensemble relationships of intrinsically disordered proteins (IDPs) are governed
by binary patterns such as the linear clustering or mixing of specific residues or residue …

Cononsolvency is an intriguing phenomenon where a polymer collapses in a mixture of
good solvents. This cosolvent-induced modulation of the polymer solubility has been …