Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …

Rab proteins are the major regulators of vesicular trafficking in eukaryotic cells. Their activity
can be tightly controlled within cells: Regulated by guanine nucleotide exchange factors …

Rab molecular switches are key players in defining membrane identity and regulating
intracellular trafficking events in eukaryotic cells. In spite of their global structural similarity …

Tumour suppressor phosphatase and tensin homologue deleted on chromosome 10 (PTEN)
is a lipid phosphatase that negatively regulates growth factor-induced survival signalling …

Rab35 is one of the first discovered members of the large Rab GTPase family, yet it received
little attention for 10 years being considered merely as a Rab1‐like GTPase. In 2006, Rab35 …

Rab GTPases are molecular switches with essential roles in mediating vesicular trafficking
and establishing organelle identity. The conversion from the inactive, cytosolic to the …

Rab GTPases and their regulatory proteins play a crucial role in vesicle-mediated
membrane trafficking. During vesicle membrane tethering Rab GTPases are activated by …

Recycling endosomes are stations that sort endocytic cargoes to their appropriate
destinations. Tubular endosomes have been characterized as a recycling endosomal …

Parkinson's disease (PD) is a complex and progressive neurodegenerative disorder with a
prevalence of approximately 0.5–1% among those aged 65–70 years. Although most of its …

Our understanding of the manner in which Rab proteins regulate intracellular vesicular
transport has progressed remarkably in the last one or two decades by application of a wide …