Although the administration of fluid is the first treatment considered in almost all cases of
circulatory failure, this therapeutic option poses two essential problems: the increase in …

OBJECTIVES: To identify research priorities in the management, epidemiology, outcome,
and pathophysiology of sepsis and septic shock. DESIGN: Shortly after publication of the …

Background Reducing the burden of death due to infection is an urgent global public health
priority. Previous studies have estimated the number of deaths associated with drug …

Acute-on-chronic liver failure (ACLF), which was described relatively recently (2013), is a
severe form of acutely decompensated cirrhosis characterised by the existence of organ …

This document on cardiovascular infection, including infective endocarditis, is the first in the
American Society of Nuclear Cardiology Imaging Indications (ASNC I2) series to assess the …

Importance The Sepsis Prediction Model (SPM) is a proprietary decision support tool
created by Epic Systems; it generates a predicting sepsis score (PSS). The model has not …

Sepsis, a critical condition marked by systemic inflammation, profoundly impacts both innate
and adaptive immunity, often resulting in lymphopenia. This immune alteration can spare …

During septic shock, fluid therapy is aimed at increasing cardiac output and improving tissue
oxygenation, but it poses two problems: it has inconsistent and transient efficacy, and it has …

Surviving critical illness does not always equate to recovery, with its aftermath frequently
complicated by post-intensive care syndrome (PICS). This syndrome consists of a collection …

Sepsis is now defined as a life-threatening syndrome of organ dysfunction triggered by a
dysregulated host response to infection, posing significant challenges in critical care. The …