Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …

Autophagy and endocytosis deliver unneeded cellular materials to lysosomes for
degradation. Beyond processing cellular waste, lysosomes release metabolites and ions …

Our understanding of lipid peroxidation in biology and medicine is rapidly evolving, as it is
increasingly implicated in various diseases but also recognized as a key part of normal cell …

Alzheimer's disease (AD) is a highly age-related cognitive decline frequently attacking the
elderly. Senescence-accelerated mouse-prone 8 (SAMP8) is an ideal model to study AD …

Alzheimer's disease (AD) represents a particular therapeutic challenge because its
aetiology is very complex, with dynamic progression from preclinical to clinical stages …

Alzheimer disease (AD) is a progressive neurodegenerative disorder associated with aging
and characterized pathologically by the presence of senile plaques, neurofibrillary tangles …

In this review there is evidence that amyloid-beta peptide is a memory enhancer at
physiological (picomolar) concentrations. Pathological overproduction of amyloid-beta leads …

Brains from persons with Alzheimer disease (AD) and its earlier stage, amnestic mild
cognitive impairment (MCI), exhibit high levels of oxidative damage, including that to …

Intranasal insulin has shown efficacy in patients with Alzheimer's disease (AD), but there are
no preclinical studies determining whether or how it reaches the brain. Here, we showed …

This retrospective review on discoveries of the roles of oxidative stress in brain of subjects
with Alzheimer disease (AD) and animal models thereof as well as brain from animal models …