Nutritional activities of luteolin in obesity and associated metabolic diseases: an eye on adipose tissues

Z Zhang, J Wang, Y Lin, J Chen, J Liu… - Critical Reviews in Food …, 2024 - Taylor & Francis
Obesity is characterized by excessive body fat accumulation and is a high-risk factor for
metabolic comorbidities, including type 2 diabetes, nonalcoholic fatty liver disease, and …

Genetics, genomics, and diet interactions in obesity in the Latin American environment

P Guevara-Ramírez, S Cadena-Ullauri… - Frontiers in …, 2022 - frontiersin.org
Obesity is a chronic disease characterized by abnormal or excessive fat accumulation that
could impact an individual's health; moreover, the World Health Organization (WHO) has …

[HTML][HTML] Evaluation of the pharmacokinetics, chylomicron inhibition, and toxicity of colchicine in rats given low doses

HM Al Nebaihi, NM Davies, DR Brocks - European Journal of …, 2024 - Elsevier
Colchicine (COL) is known for its ability to inhibit the formation of intestinal chylomicrons and
has been utilized as a non-surgical tool to explore drug absorption via the intestinal …

Acetaminophen-induced hepatotoxicity in obesity and nonalcoholic fatty liver disease: a critical review

K Begriche, C Penhoat, P Bernabeu-Gentey, J Massart… - Livers, 2023 - mdpi.com
The epidemic of obesity, type 2 diabetes and nonalcoholic liver disease (NAFLD) favors
drug consumption, which augments the risk of adverse events including liver injury. For …

Pharmacokinetics of cycloheximide in rats and evaluation of its effect as a blocker of intestinal lymph formation

HM Al Nebaihi, NM Davies, DR Brocks - European Journal of …, 2023 - Elsevier
Cycloheximide (CHX) has been used to reduce the flow of intestinal lymph and as a non-
surgical tool to study drug absorption via the intestinal lymphatics. Pharmacokinetic …

[HTML][HTML] The effect of maternal high-fat or high-carbohydrate diet during pregnancy and lactation on cytochrome P450 2D (CYP2D) in the liver and brain of rat offspring

W Kuban, A Haduch, E Bromek… - International Journal of …, 2024 - mdpi.com
Cytochrome P450 2D (CYP2D) is important in psychopharmacology as it is engaged in the
metabolism of drugs, neurosteroids and neurotransmitters. An unbalanced maternal diet …

Maternal-placental-fetal drug metabolism is altered by late gestation undernutrition in the pregnant ewe

AS Meakin, JRT Darby, SL Holman, MD Wiese… - Life Sciences, 2022 - Elsevier
Background Maternal undernutrition during pregnancy disrupts both fetal growth and
development with perturbations to certain physiological processes within the maternal-fetal …

Is platelet responsiveness to clopidogrel attenuated in overweight or obese patients and why? A reverse translational study in mice

LP Jiang, JZ Ji, PX Ge, T Zhu, QY Mi… - British Journal of …, 2022 - Wiley Online Library
Background and Purpose Overweight or obese patients exhibit poorer platelet responses to
clopidogrel. However, the mechanisms behind this phenotype remain to be elucidated …

Obesity-related genomic instability and altered xenobiotic metabolism: possible consequences for cancer risk and chemotherapy

EE Bankoglu, H Stopper - Expert Reviews in Molecular Medicine, 2022 - cambridge.org
The increase in the prevalence of obesity has led to an elevated risk for several associated
diseases including cancer. Several studies have investigated the DNA damage in human …

Hepatic cytochrome P450 function is reduced by life-long Western diet consumption in guinea pig independent of birth weight

MD Wiese, AS Meakin, TJ Varcoe, JRT Darby, O Sarr… - Life Sciences, 2021 - Elsevier
Introduction Non-alcoholic fatty liver disease (NAFLD) is characterised by accumulation of
triglycerides and cholesterol within the liver and dysregulation of specific hepatic …