Exosomes
Exosomes are small, single-membrane, secreted organelles of∼ 30 to∼ 200 nm in
diameter that have the same topology as the cell and are enriched in selected proteins …
diameter that have the same topology as the cell and are enriched in selected proteins …
Cellular signalling by primary cilia in development, organ function and disease
Primary cilia project in a single copy from the surface of most vertebrate cell types; they
detect and transmit extracellular cues to regulate diverse cellular processes during …
detect and transmit extracellular cues to regulate diverse cellular processes during …
Exploiting the biogenesis of extracellular vesicles for bioengineering and therapeutic cargo loading
J Rädler, D Gupta, A Zickler, SEL Andaloussi - Molecular Therapy, 2023 - cell.com
Extracellular vesicles (EVs) are gaining increasing attention for diagnostic and therapeutic
applications in various diseases. These natural nanoparticles benefit from favorable safety …
applications in various diseases. These natural nanoparticles benefit from favorable safety …
Signaling through the primary cilium
The presence of single, non-motile “primary” cilia on the surface of epithelial cells has been
well described since the 1960s. However, for decades these organelles were believed to be …
well described since the 1960s. However, for decades these organelles were believed to be …
Establishing and regulating the composition of cilia for signal transduction
The primary cilium is a hair-like surface-exposed organelle of the eukaryotic cell that
decodes a variety of signals—such as odorants, light and Hedgehog morphogens—by …
decodes a variety of signals—such as odorants, light and Hedgehog morphogens—by …
[HTML][HTML] Non-syndromic retinitis pigmentosa
SK Verbakel, RAC van Huet, CJF Boon… - Progress in retinal and …, 2018 - Elsevier
Retinitis pigmentosa (RP) encompasses a group of inherited retinal dystrophies
characterized by the primary degeneration of rod and cone photoreceptors. RP is a leading …
characterized by the primary degeneration of rod and cone photoreceptors. RP is a leading …
Emerging mechanistic understanding of cilia function in cellular signalling
Primary cilia are solitary, immotile sensory organelles present on most cells in the body that
participate broadly in human health, physiology and disease. Cilia generate a unique …
participate broadly in human health, physiology and disease. Cilia generate a unique …
Biogenesis and function of ESCRT-dependent extracellular vesicles
T Juan, M Fürthauer - Seminars in cell & developmental biology, 2018 - Elsevier
From bacteria to humans, cells secrete a large variety of membrane-bound extracellular
vesicles. Only relatively recently has it however started to become clear that the exovesicular …
vesicles. Only relatively recently has it however started to become clear that the exovesicular …
[HTML][HTML] A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility
Chemical synapses between axons and dendrites mediate neuronal intercellular
communication. Here, we describe a synapse between axons and primary cilia: the axo …
communication. Here, we describe a synapse between axons and primary cilia: the axo …
Map** of neuronal and glial primary cilia contactome and connectome in the human cerebral cortex
Primary cilia act as antenna receivers of environmental signals and enable effective
neuronal or glial responses. Disruption of their function is associated with circuit disorders …
neuronal or glial responses. Disruption of their function is associated with circuit disorders …