[HTML][HTML] The basic immunology of asthma
H Hammad, BN Lambrecht - Cell, 2021 - cell.com
In many asthmatics, chronic airway inflammation is driven by IL-4-, IL-5-, and IL-13-
producing Th2 cells or ILC2s. Type 2 cytokines promote hallmark features of the disease …
producing Th2 cells or ILC2s. Type 2 cytokines promote hallmark features of the disease …
The roles of tissue-resident memory T cells in lung diseases
R Yuan, J Yu, Z Jiao, J Li, F Wu, R Yan… - Frontiers in …, 2021 - frontiersin.org
The unique environment of the lungs is protected by complex immune interactions. Human
lung tissue-resident memory T cells (TRM) have been shown to position at the pathogen …
lung tissue-resident memory T cells (TRM) have been shown to position at the pathogen …
Expansible residence decentralizes immune homeostasis
In metazoans, specific tasks are relegated to dedicated organs that are established early in
development, occupy discrete locations and typically remain fixed in size. The adult immune …
development, occupy discrete locations and typically remain fixed in size. The adult immune …
Two sides of the same coin: Protective versus pathogenic CD4+ resident memory T cells
AE Oja, RAW van Lier, P Hombrink - Science immunology, 2022 - science.org
The ability of the adaptive immune system to form memory is key to providing protection
against secondary infections. Resident memory T cells (TRM) are specialized T cell …
against secondary infections. Resident memory T cells (TRM) are specialized T cell …
Tissue-resident immunity in the lung: a first-line defense at the environmental interface
The lung is a vital organ that incessantly faces external environmental challenges. Its
homeostasis and unimpeded vital function are ensured by the respiratory epithelium …
homeostasis and unimpeded vital function are ensured by the respiratory epithelium …
Integrating resident memory into T cell differentiation models
Highlights•T RM reside in tissues without recirculating.•Memory T cells are more
heterogenous than implied by a few discrete subset labels.•Popular subset labels do not …
heterogenous than implied by a few discrete subset labels.•Popular subset labels do not …
Research progress on icariin, a traditional Chinese medicine extract, in the treatment of asthma
J Yuan, Z Tong, Y Dong, J Zhao… - Allergologia et …, 2022 - all-imm.com
Bronchial asthma is a common chronic airway disease, and long-term management of
asthma is the focus and challenge of clinical treatment. Glucocorticoids are often used as the …
asthma is the focus and challenge of clinical treatment. Glucocorticoids are often used as the …
S1PR2 inhibition attenuates allergic asthma possibly by regulating autophagy
H Liu, L Li, Z Chen, Y Song, W Liu, G Gao… - Frontiers in …, 2021 - frontiersin.org
This study is to investigate the role of Sphingosine-1-phosphate (S1P) in the asthma
progression, and the involvement of autophagy. Airway remodeling mice were subjected to …
progression, and the involvement of autophagy. Airway remodeling mice were subjected to …
[HTML][HTML] Overlap** and distinct features of viral and allergen immunity in the human lung
Immunity in the human respiratory tract is provided by a diverse range of tissue-resident
cells, including specialized epithelial and macrophage populations and a network of innate …
cells, including specialized epithelial and macrophage populations and a network of innate …
MCK2-mediated MCMV infection of macrophages and virus dissemination to the salivary gland depends on MHC class I molecules
Murine cytomegalovirus (MCMV) infection of macrophages relies on MCMV-encoded
chemokine 2 (MCK2), while infection of fibroblasts occurs independently of MCK2. Recently …
chemokine 2 (MCK2), while infection of fibroblasts occurs independently of MCK2. Recently …