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Lymphopenia in COVID‐19: Therapeutic opportunities
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is uncontrollably spread
all over the world. The host immune responses strongly try to confront it with all the potential …
all over the world. The host immune responses strongly try to confront it with all the potential …
[HTML][HTML] Liver toxicity as a limiting factor to the increasing use of immune checkpoint inhibitors
Immune checkpoint inhibitors (ICIs) improve clinical outcomes in patients suffering from
different types of cancer. Liver toxicity is one of the immune-related adverse events …
different types of cancer. Liver toxicity is one of the immune-related adverse events …
Comprehensive in vitro characterization of PD-L1 small molecule inhibitors
Blockade of the programmed cell death 1 (PD-1)/programmed cell death-ligand 1 (PD-L1)
interaction has emerged as a powerful strategy in cancer immunotherapy. Recently, there …
interaction has emerged as a powerful strategy in cancer immunotherapy. Recently, there …
Blockade of MIF–CD74 signalling on macrophages and dendritic cells restores the antitumour immune response against metastatic melanoma
Mounting an effective immune response against cancer requires the activation of innate and
adaptive immune cells. Metastatic melanoma is the most aggressive form of skin cancer …
adaptive immune cells. Metastatic melanoma is the most aggressive form of skin cancer …
Hypoxia induces mitochondrial defect that promotes T cell exhaustion in tumor microenvironment through MYC-regulated pathways
YN Liu, JF Yang, DJ Huang, HH Ni, CX Zhang… - Frontiers in …, 2020 - frontiersin.org
T cell exhaustion is an obstacle to immunotherapy for solid tumors. An understanding of the
mechanism by which T cells develop this phenotype in solid tumors is needed. Here …
mechanism by which T cells develop this phenotype in solid tumors is needed. Here …
Galectin-9 promotes natural killer cells activity via interaction with CD44
Natural killer (NK) cells are a potent innate source of cytokines and cytoplasmic granules.
Their effector functions are tightly synchronized by the balance between the stimulatory and …
Their effector functions are tightly synchronized by the balance between the stimulatory and …
The quality of SARS-CoV-2–specific T cell functions differs in patients with mild/moderate versus severe disease, and T cells expressing coinhibitory receptors are …
Understanding the function of SARS-CoV-2 Ag-specific T cells is crucial for the monitoring of
antiviral immunity and vaccine design. Currently, both impaired and robust T cell immunity is …
antiviral immunity and vaccine design. Currently, both impaired and robust T cell immunity is …
T cell perturbations persist for at least 6 months following hospitalization for COVID-19
COVID-19 is being extensively studied, and much remains unknown regarding the long-term
consequences of the disease on immune cells. The different arms of the immune system are …
consequences of the disease on immune cells. The different arms of the immune system are …
Analysis of SARS-CoV-2 isolates, namely the Wuhan strain, Delta variant, and Omicron variant, identifies differential immune profiles
There is an urgent need to better understand the impact of different severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) variants on immune response and disease …
syndrome coronavirus 2 (SARS-CoV-2) variants on immune response and disease …
Immune-related cholangitis induced by immune checkpoint inhibitors: a systematic review of clinical features and management
B Pi, J Wang, Y Tong, Q Yang, F Lv… - European Journal of …, 2021 - journals.lww.com
Methods We retrieved the literature from the PubMed database for case reports and series of
IMC induced by ICIs. IMC was then classified as small-ducts type, large-ducts type and …
IMC induced by ICIs. IMC was then classified as small-ducts type, large-ducts type and …